An evaluation of the prognostic significance of alpha-1-antitrypsin expression in adenocarcinomas of the lung: an immunohistochemical analysis.

Expression of alpha-1-antitrypsin (AAT) in tumour cells of 102 surgically resected lung adenocarcinomas was examined by immunohistochemical method using anti-AAT antiserum. While only 13 cases (13%) were negative for AAT expression, 89 cases (87%) contained AAT at varying degrees. The degree of AAT-...

Descripción completa

Detalles Bibliográficos
Autores principales: Higashiyama, M., Doi, O., Kodama, K., Yokouchi, H., Tateishi, R.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1992
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1977730/
https://www.ncbi.nlm.nih.gov/pubmed/1739634
_version_ 1782135324947775488
author Higashiyama, M.
Doi, O.
Kodama, K.
Yokouchi, H.
Tateishi, R.
author_facet Higashiyama, M.
Doi, O.
Kodama, K.
Yokouchi, H.
Tateishi, R.
author_sort Higashiyama, M.
collection PubMed
description Expression of alpha-1-antitrypsin (AAT) in tumour cells of 102 surgically resected lung adenocarcinomas was examined by immunohistochemical method using anti-AAT antiserum. While only 13 cases (13%) were negative for AAT expression, 89 cases (87%) contained AAT at varying degrees. The degree of AAT-positive tumour cells was significantly higher in advanced cases than in early cases. Clinical follow-up study of the patients, particularly in stage I, showed that strongly AAT-positive cases have poor prognosis than weak-to-moderately AAT-positive or AAT-negative cases. Thus, AAT expression status in tumour cells of lung adenocarcinoma may be a biological marker of prognostic significance in regard to tumour growth. IMAGES:
format Text
id pubmed-1977730
institution National Center for Biotechnology Information
language English
publishDate 1992
publisher Nature Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-19777302009-09-10 An evaluation of the prognostic significance of alpha-1-antitrypsin expression in adenocarcinomas of the lung: an immunohistochemical analysis. Higashiyama, M. Doi, O. Kodama, K. Yokouchi, H. Tateishi, R. Br J Cancer Research Article Expression of alpha-1-antitrypsin (AAT) in tumour cells of 102 surgically resected lung adenocarcinomas was examined by immunohistochemical method using anti-AAT antiserum. While only 13 cases (13%) were negative for AAT expression, 89 cases (87%) contained AAT at varying degrees. The degree of AAT-positive tumour cells was significantly higher in advanced cases than in early cases. Clinical follow-up study of the patients, particularly in stage I, showed that strongly AAT-positive cases have poor prognosis than weak-to-moderately AAT-positive or AAT-negative cases. Thus, AAT expression status in tumour cells of lung adenocarcinoma may be a biological marker of prognostic significance in regard to tumour growth. IMAGES: Nature Publishing Group 1992-02 /pmc/articles/PMC1977730/ /pubmed/1739634 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Higashiyama, M.
Doi, O.
Kodama, K.
Yokouchi, H.
Tateishi, R.
An evaluation of the prognostic significance of alpha-1-antitrypsin expression in adenocarcinomas of the lung: an immunohistochemical analysis.
title An evaluation of the prognostic significance of alpha-1-antitrypsin expression in adenocarcinomas of the lung: an immunohistochemical analysis.
title_full An evaluation of the prognostic significance of alpha-1-antitrypsin expression in adenocarcinomas of the lung: an immunohistochemical analysis.
title_fullStr An evaluation of the prognostic significance of alpha-1-antitrypsin expression in adenocarcinomas of the lung: an immunohistochemical analysis.
title_full_unstemmed An evaluation of the prognostic significance of alpha-1-antitrypsin expression in adenocarcinomas of the lung: an immunohistochemical analysis.
title_short An evaluation of the prognostic significance of alpha-1-antitrypsin expression in adenocarcinomas of the lung: an immunohistochemical analysis.
title_sort evaluation of the prognostic significance of alpha-1-antitrypsin expression in adenocarcinomas of the lung: an immunohistochemical analysis.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1977730/
https://www.ncbi.nlm.nih.gov/pubmed/1739634
work_keys_str_mv AT higashiyamam anevaluationoftheprognosticsignificanceofalpha1antitrypsinexpressioninadenocarcinomasofthelunganimmunohistochemicalanalysis
AT doio anevaluationoftheprognosticsignificanceofalpha1antitrypsinexpressioninadenocarcinomasofthelunganimmunohistochemicalanalysis
AT kodamak anevaluationoftheprognosticsignificanceofalpha1antitrypsinexpressioninadenocarcinomasofthelunganimmunohistochemicalanalysis
AT yokouchih anevaluationoftheprognosticsignificanceofalpha1antitrypsinexpressioninadenocarcinomasofthelunganimmunohistochemicalanalysis
AT tateishir anevaluationoftheprognosticsignificanceofalpha1antitrypsinexpressioninadenocarcinomasofthelunganimmunohistochemicalanalysis
AT higashiyamam evaluationoftheprognosticsignificanceofalpha1antitrypsinexpressioninadenocarcinomasofthelunganimmunohistochemicalanalysis
AT doio evaluationoftheprognosticsignificanceofalpha1antitrypsinexpressioninadenocarcinomasofthelunganimmunohistochemicalanalysis
AT kodamak evaluationoftheprognosticsignificanceofalpha1antitrypsinexpressioninadenocarcinomasofthelunganimmunohistochemicalanalysis
AT yokouchih evaluationoftheprognosticsignificanceofalpha1antitrypsinexpressioninadenocarcinomasofthelunganimmunohistochemicalanalysis
AT tateishir evaluationoftheprognosticsignificanceofalpha1antitrypsinexpressioninadenocarcinomasofthelunganimmunohistochemicalanalysis

Ejemplares similares