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Loss of heterozygosity on chromosomes 1 and 11 in carcinoma of the pancreas.

Little is known of the molecular-genetic changes in carcinoma of the pancreas (CaP). In order to investigate the allele loss, or loss of heterozygosity (LOH), in CaP, we studied 13 patients with exocrine CaP and two with endocrine CaP using restriction fragment length polymorphism analysis. Twenty p...

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Autores principales: Ding, S. F., Habib, N. A., Delhanty, J. D., Bowles, L., Greco, L., Wood, C., Williamson, R. C., Dooley, J. S.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1992
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1977778/
https://www.ncbi.nlm.nih.gov/pubmed/1352124
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author Ding, S. F.
Habib, N. A.
Delhanty, J. D.
Bowles, L.
Greco, L.
Wood, C.
Williamson, R. C.
Dooley, J. S.
author_facet Ding, S. F.
Habib, N. A.
Delhanty, J. D.
Bowles, L.
Greco, L.
Wood, C.
Williamson, R. C.
Dooley, J. S.
author_sort Ding, S. F.
collection PubMed
description Little is known of the molecular-genetic changes in carcinoma of the pancreas (CaP). In order to investigate the allele loss, or loss of heterozygosity (LOH), in CaP, we studied 13 patients with exocrine CaP and two with endocrine CaP using restriction fragment length polymorphism analysis. Twenty probes assigned to chromosomes 1, 5, 7, 9, 11, 12, 13, 14, 16, 17 and 18 were used. The frequency of LOH, or fractional allele loss (FAL), was found in two endocrine tumours to be 0.333 and 0.455 respectively; and FAL in 13 oxocrine tumours ranged from 0 to 0.25. Allele loss was shown in both exocrine and endocrine tumours by the probes Lambda MS1 at 1p33-35, and pMS51 at 11q13. Probes for other chromosomes have as yet shown no consistent LOH. In conclusion, the study showed LOH on chromosomes 1 and 11 in both exocrine and endocrine CaP. IMAGES:
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spelling pubmed-19777782009-09-10 Loss of heterozygosity on chromosomes 1 and 11 in carcinoma of the pancreas. Ding, S. F. Habib, N. A. Delhanty, J. D. Bowles, L. Greco, L. Wood, C. Williamson, R. C. Dooley, J. S. Br J Cancer Research Article Little is known of the molecular-genetic changes in carcinoma of the pancreas (CaP). In order to investigate the allele loss, or loss of heterozygosity (LOH), in CaP, we studied 13 patients with exocrine CaP and two with endocrine CaP using restriction fragment length polymorphism analysis. Twenty probes assigned to chromosomes 1, 5, 7, 9, 11, 12, 13, 14, 16, 17 and 18 were used. The frequency of LOH, or fractional allele loss (FAL), was found in two endocrine tumours to be 0.333 and 0.455 respectively; and FAL in 13 oxocrine tumours ranged from 0 to 0.25. Allele loss was shown in both exocrine and endocrine tumours by the probes Lambda MS1 at 1p33-35, and pMS51 at 11q13. Probes for other chromosomes have as yet shown no consistent LOH. In conclusion, the study showed LOH on chromosomes 1 and 11 in both exocrine and endocrine CaP. IMAGES: Nature Publishing Group 1992-06 /pmc/articles/PMC1977778/ /pubmed/1352124 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Ding, S. F.
Habib, N. A.
Delhanty, J. D.
Bowles, L.
Greco, L.
Wood, C.
Williamson, R. C.
Dooley, J. S.
Loss of heterozygosity on chromosomes 1 and 11 in carcinoma of the pancreas.
title Loss of heterozygosity on chromosomes 1 and 11 in carcinoma of the pancreas.
title_full Loss of heterozygosity on chromosomes 1 and 11 in carcinoma of the pancreas.
title_fullStr Loss of heterozygosity on chromosomes 1 and 11 in carcinoma of the pancreas.
title_full_unstemmed Loss of heterozygosity on chromosomes 1 and 11 in carcinoma of the pancreas.
title_short Loss of heterozygosity on chromosomes 1 and 11 in carcinoma of the pancreas.
title_sort loss of heterozygosity on chromosomes 1 and 11 in carcinoma of the pancreas.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1977778/
https://www.ncbi.nlm.nih.gov/pubmed/1352124
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