Antigenic modulation of metastatic breast and ovary carcinoma cells by intracavitary injection of IFN-alpha.

Antigenic modulation of major histocompatibility and tumour associated antigens was observed in neoplastic cells obtained from patients with pleural and abdominal effusions of breast and ovary carcinomas following a single intracavitary dose of 18 x 10(6) U recombinant IFN-alpha. This regimen result...

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Autores principales: Giacomini, P., Mottolese, M., Fraioli, R., Benevolo, M., Venturo, I., Natali, P. G.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1992
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1977801/
https://www.ncbi.nlm.nih.gov/pubmed/1503908
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author Giacomini, P.
Mottolese, M.
Fraioli, R.
Benevolo, M.
Venturo, I.
Natali, P. G.
author_facet Giacomini, P.
Mottolese, M.
Fraioli, R.
Benevolo, M.
Venturo, I.
Natali, P. G.
author_sort Giacomini, P.
collection PubMed
description Antigenic modulation of major histocompatibility and tumour associated antigens was observed in neoplastic cells obtained from patients with pleural and abdominal effusions of breast and ovary carcinomas following a single intracavitary dose of 18 x 10(6) U recombinant IFN-alpha. This regimen resulted in antigenic modulation in seven out of 11 tested cases, suggesting a potential, although limited, responsiveness of at least a fraction of breast and ovary carcinoma cells to in situ biomodification with IFN-alpha.
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spelling pubmed-19778012009-09-10 Antigenic modulation of metastatic breast and ovary carcinoma cells by intracavitary injection of IFN-alpha. Giacomini, P. Mottolese, M. Fraioli, R. Benevolo, M. Venturo, I. Natali, P. G. Br J Cancer Research Article Antigenic modulation of major histocompatibility and tumour associated antigens was observed in neoplastic cells obtained from patients with pleural and abdominal effusions of breast and ovary carcinomas following a single intracavitary dose of 18 x 10(6) U recombinant IFN-alpha. This regimen resulted in antigenic modulation in seven out of 11 tested cases, suggesting a potential, although limited, responsiveness of at least a fraction of breast and ovary carcinoma cells to in situ biomodification with IFN-alpha. Nature Publishing Group 1992-08 /pmc/articles/PMC1977801/ /pubmed/1503908 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Giacomini, P.
Mottolese, M.
Fraioli, R.
Benevolo, M.
Venturo, I.
Natali, P. G.
Antigenic modulation of metastatic breast and ovary carcinoma cells by intracavitary injection of IFN-alpha.
title Antigenic modulation of metastatic breast and ovary carcinoma cells by intracavitary injection of IFN-alpha.
title_full Antigenic modulation of metastatic breast and ovary carcinoma cells by intracavitary injection of IFN-alpha.
title_fullStr Antigenic modulation of metastatic breast and ovary carcinoma cells by intracavitary injection of IFN-alpha.
title_full_unstemmed Antigenic modulation of metastatic breast and ovary carcinoma cells by intracavitary injection of IFN-alpha.
title_short Antigenic modulation of metastatic breast and ovary carcinoma cells by intracavitary injection of IFN-alpha.
title_sort antigenic modulation of metastatic breast and ovary carcinoma cells by intracavitary injection of ifn-alpha.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1977801/
https://www.ncbi.nlm.nih.gov/pubmed/1503908
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