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Molecular and biological properties of an abrin A chain immunotoxin designed for therapy of human small cell lung cancer.

An immunotoxin (IT) comprising abrin A chain attached to the mouse monoclonal antibody SWA11, recognising a cell surface antigen highly associated with human small cell lung cancer (SCLC), was synthesised using a hindered disulphide crosslinker, N-succinimidyl 3-(2-pyridyldithio) butyrate (SPDB), an...

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Detalles Bibliográficos
Autores principales:	Wawrzynczak, E. J., Zangemeister-Wittke, U., Waibel, R., Henry, R. V., Parnell, G. D., Cumber, A. J., Jones, M., Stahel, R. A.
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 1992
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1977812/ https://www.ncbi.nlm.nih.gov/pubmed/1323991

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