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Photodynamic therapy with chlorins for diffuse malignant mesothelioma: initial clinical results.
Four patients underwent intraoperative photodynamic therapy after surgery with meso-tetra-(hydroxyphenyl)-chlorin (mTHPC-PDT) for diffuse malignant mesothelioma. Preliminary procedures were performed in two patients in order to establish the efficacy of mTHPC-PDT and to optimise its tumoricidal effe...
Autores principales: | , , , , , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
1991
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1977841/ https://www.ncbi.nlm.nih.gov/pubmed/1764375 |
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author | Ris, H. B. Altermatt, H. J. Inderbitzi, R. Hess, R. Nachbur, B. Stewart, J. C. Wang, Q. Lim, C. K. Bonnett, R. Berenbaum, M. C. |
author_facet | Ris, H. B. Altermatt, H. J. Inderbitzi, R. Hess, R. Nachbur, B. Stewart, J. C. Wang, Q. Lim, C. K. Bonnett, R. Berenbaum, M. C. |
author_sort | Ris, H. B. |
collection | PubMed |
description | Four patients underwent intraoperative photodynamic therapy after surgery with meso-tetra-(hydroxyphenyl)-chlorin (mTHPC-PDT) for diffuse malignant mesothelioma. Preliminary procedures were performed in two patients in order to establish the efficacy of mTHPC-PDT and to optimise its tumoricidal effect. The tumoricidal effect was related to the mTHPC dose, light dose and the time interval between sensitation and activation. 0.3 mg kg-1 mTHPC activated after 48 h with 10 Joules cm-2 of non-thermal laser light at 650 nm resulted in a 10 mm deep tumour infarction, due to tumour vessel necrosis and thrombosis. The mTHPC tissue concentration was up to 14 times higher in the tumour than in normal tissues. Skin photosensitivity was mild, dose dependent and occurred 3 to 10 days after administration of mTHPC. According to the results obtained, intraoperative mTHPC-PDT was performed following pleuropneumonectomy in two, pleurectomy and lobectomy in one and pleurectomy in one patient. Ten Joules cm-2 were delivered to the diaphragm and the costophrenic sulcus and 5 Joules cm-2 to the remaining thoracic cavity. The postoperative course was marked by loss of appetite, fluid retention, hypoproteinemia and severe chest pain. One patient succumbed from aspiration pneumonia. The remaining patients developed no neural or vascular alterations and no bronchial stump insufficiency during follow-up. mTHPC-PDT following surgical tumour resection deserves further evaluation in good risk patients with diffuse malignant mesothelioma. IMAGES: |
format | Text |
id | pubmed-1977841 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1991 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-19778412009-09-10 Photodynamic therapy with chlorins for diffuse malignant mesothelioma: initial clinical results. Ris, H. B. Altermatt, H. J. Inderbitzi, R. Hess, R. Nachbur, B. Stewart, J. C. Wang, Q. Lim, C. K. Bonnett, R. Berenbaum, M. C. Br J Cancer Research Article Four patients underwent intraoperative photodynamic therapy after surgery with meso-tetra-(hydroxyphenyl)-chlorin (mTHPC-PDT) for diffuse malignant mesothelioma. Preliminary procedures were performed in two patients in order to establish the efficacy of mTHPC-PDT and to optimise its tumoricidal effect. The tumoricidal effect was related to the mTHPC dose, light dose and the time interval between sensitation and activation. 0.3 mg kg-1 mTHPC activated after 48 h with 10 Joules cm-2 of non-thermal laser light at 650 nm resulted in a 10 mm deep tumour infarction, due to tumour vessel necrosis and thrombosis. The mTHPC tissue concentration was up to 14 times higher in the tumour than in normal tissues. Skin photosensitivity was mild, dose dependent and occurred 3 to 10 days after administration of mTHPC. According to the results obtained, intraoperative mTHPC-PDT was performed following pleuropneumonectomy in two, pleurectomy and lobectomy in one and pleurectomy in one patient. Ten Joules cm-2 were delivered to the diaphragm and the costophrenic sulcus and 5 Joules cm-2 to the remaining thoracic cavity. The postoperative course was marked by loss of appetite, fluid retention, hypoproteinemia and severe chest pain. One patient succumbed from aspiration pneumonia. The remaining patients developed no neural or vascular alterations and no bronchial stump insufficiency during follow-up. mTHPC-PDT following surgical tumour resection deserves further evaluation in good risk patients with diffuse malignant mesothelioma. IMAGES: Nature Publishing Group 1991-12 /pmc/articles/PMC1977841/ /pubmed/1764375 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Research Article Ris, H. B. Altermatt, H. J. Inderbitzi, R. Hess, R. Nachbur, B. Stewart, J. C. Wang, Q. Lim, C. K. Bonnett, R. Berenbaum, M. C. Photodynamic therapy with chlorins for diffuse malignant mesothelioma: initial clinical results. |
title | Photodynamic therapy with chlorins for diffuse malignant mesothelioma: initial clinical results. |
title_full | Photodynamic therapy with chlorins for diffuse malignant mesothelioma: initial clinical results. |
title_fullStr | Photodynamic therapy with chlorins for diffuse malignant mesothelioma: initial clinical results. |
title_full_unstemmed | Photodynamic therapy with chlorins for diffuse malignant mesothelioma: initial clinical results. |
title_short | Photodynamic therapy with chlorins for diffuse malignant mesothelioma: initial clinical results. |
title_sort | photodynamic therapy with chlorins for diffuse malignant mesothelioma: initial clinical results. |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1977841/ https://www.ncbi.nlm.nih.gov/pubmed/1764375 |
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