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Phase I and pharmacokinetic study of D-verapamil and doxorubicin.

The calcium antagonist verapamil (a mixture of D- and L-racemers) is a potent modulator of the multi-drug resistance phenotype in vitro at a concentration of 6 microM. Clinical studies have shown dose-limiting toxicity of hypotension and heart block when plasma levels approach the concentrations act...

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Detalles Bibliográficos
Autores principales:	Bissett, D., Kerr, D. J., Cassidy, J., Meredith, P., Traugott, U., Kaye, S. B.
Formato:	Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 1991
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1977847/ https://www.ncbi.nlm.nih.gov/pubmed/1684909

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