Growth factors in ovarian cancer.

Epidermal growth factor and transforming growth factor alpha are two peptides which bind to the epidermal growth factor receptor. One hundred and seventy-four samples from 133 patients with ovarian cancer were examined for EGF and TGF alpha. EGF was detected in only 27.6% of samples while TGF alpha...

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Detalles Bibliográficos
Autores principales: Owens, O. J., Stewart, C., Leake, R. E.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1991
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1977857/
https://www.ncbi.nlm.nih.gov/pubmed/1764384
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author Owens, O. J.
Stewart, C.
Leake, R. E.
author_facet Owens, O. J.
Stewart, C.
Leake, R. E.
author_sort Owens, O. J.
collection PubMed
description Epidermal growth factor and transforming growth factor alpha are two peptides which bind to the epidermal growth factor receptor. One hundred and seventy-four samples from 133 patients with ovarian cancer were examined for EGF and TGF alpha. EGF was detected in only 27.6% of samples while TGF alpha was present in 88.5%. The median values for TGF alpha presence were at least 10-fold greater than those of EGF. There was no statistical difference between either TGF alpha or EGF levels and degree of differentiation of the tumours. There was no statistical difference between stage three and four in relation to concentration of either peptide. Median concentration did not differ significantly among the histological sub-groups.
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spelling pubmed-19778572009-09-10 Growth factors in ovarian cancer. Owens, O. J. Stewart, C. Leake, R. E. Br J Cancer Research Article Epidermal growth factor and transforming growth factor alpha are two peptides which bind to the epidermal growth factor receptor. One hundred and seventy-four samples from 133 patients with ovarian cancer were examined for EGF and TGF alpha. EGF was detected in only 27.6% of samples while TGF alpha was present in 88.5%. The median values for TGF alpha presence were at least 10-fold greater than those of EGF. There was no statistical difference between either TGF alpha or EGF levels and degree of differentiation of the tumours. There was no statistical difference between stage three and four in relation to concentration of either peptide. Median concentration did not differ significantly among the histological sub-groups. Nature Publishing Group 1991-12 /pmc/articles/PMC1977857/ /pubmed/1764384 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Owens, O. J.
Stewart, C.
Leake, R. E.
Growth factors in ovarian cancer.
title Growth factors in ovarian cancer.
title_full Growth factors in ovarian cancer.
title_fullStr Growth factors in ovarian cancer.
title_full_unstemmed Growth factors in ovarian cancer.
title_short Growth factors in ovarian cancer.
title_sort growth factors in ovarian cancer.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1977857/
https://www.ncbi.nlm.nih.gov/pubmed/1764384
work_keys_str_mv AT owensoj growthfactorsinovariancancer
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