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Regional delivery of microspheres to liver metastases: the effects of particle size and concentration on intrahepatic distribution.
There is increasing interest in the use of microspheres, loaded with chemotherapeutic agents, for regional therapy to hepatic metastases. It is necessary to deliver these particles predominately to tumour rather than to normal liver. This study investigates factors influencing the distribution of re...
Autores principales: | , , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
1991
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1977859/ https://www.ncbi.nlm.nih.gov/pubmed/1764363 |
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author | Anderson, J. H. Angerson, W. J. Willmott, N. Kerr, D. J. McArdle, C. S. Cooke, T. G. |
author_facet | Anderson, J. H. Angerson, W. J. Willmott, N. Kerr, D. J. McArdle, C. S. Cooke, T. G. |
author_sort | Anderson, J. H. |
collection | PubMed |
description | There is increasing interest in the use of microspheres, loaded with chemotherapeutic agents, for regional therapy to hepatic metastases. It is necessary to deliver these particles predominately to tumour rather than to normal liver. This study investigates factors influencing the distribution of regionally injected microspheres. Discreet tumour was induced in rats by subcapsular hepatic inoculations of HSN cells. At 20 days, 12.5 microns, 25 microns or 40 microns diameter, radiolabelled albumin microspheres were administered, in various concentrations, via the gastroduodenal artery. Tumour to normal liver microsphere distribution ratios were determined and median values ranged from 0.1 (0.2 mg ml-1 12.5 microns microspheres) to 1.8 (20 mg ml 40 microns microspheres). Concentrated suspensions (20 mg ml-1) of large microspheres (40 microns) produced the most favourable tumour to normal liver distribution ratios. These results not only have implications for the therapeutic administration of microspheres but also for their use in blood-flow studies. |
format | Text |
id | pubmed-1977859 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1991 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-19778592009-09-10 Regional delivery of microspheres to liver metastases: the effects of particle size and concentration on intrahepatic distribution. Anderson, J. H. Angerson, W. J. Willmott, N. Kerr, D. J. McArdle, C. S. Cooke, T. G. Br J Cancer Research Article There is increasing interest in the use of microspheres, loaded with chemotherapeutic agents, for regional therapy to hepatic metastases. It is necessary to deliver these particles predominately to tumour rather than to normal liver. This study investigates factors influencing the distribution of regionally injected microspheres. Discreet tumour was induced in rats by subcapsular hepatic inoculations of HSN cells. At 20 days, 12.5 microns, 25 microns or 40 microns diameter, radiolabelled albumin microspheres were administered, in various concentrations, via the gastroduodenal artery. Tumour to normal liver microsphere distribution ratios were determined and median values ranged from 0.1 (0.2 mg ml-1 12.5 microns microspheres) to 1.8 (20 mg ml 40 microns microspheres). Concentrated suspensions (20 mg ml-1) of large microspheres (40 microns) produced the most favourable tumour to normal liver distribution ratios. These results not only have implications for the therapeutic administration of microspheres but also for their use in blood-flow studies. Nature Publishing Group 1991-12 /pmc/articles/PMC1977859/ /pubmed/1764363 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Research Article Anderson, J. H. Angerson, W. J. Willmott, N. Kerr, D. J. McArdle, C. S. Cooke, T. G. Regional delivery of microspheres to liver metastases: the effects of particle size and concentration on intrahepatic distribution. |
title | Regional delivery of microspheres to liver metastases: the effects of particle size and concentration on intrahepatic distribution. |
title_full | Regional delivery of microspheres to liver metastases: the effects of particle size and concentration on intrahepatic distribution. |
title_fullStr | Regional delivery of microspheres to liver metastases: the effects of particle size and concentration on intrahepatic distribution. |
title_full_unstemmed | Regional delivery of microspheres to liver metastases: the effects of particle size and concentration on intrahepatic distribution. |
title_short | Regional delivery of microspheres to liver metastases: the effects of particle size and concentration on intrahepatic distribution. |
title_sort | regional delivery of microspheres to liver metastases: the effects of particle size and concentration on intrahepatic distribution. |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1977859/ https://www.ncbi.nlm.nih.gov/pubmed/1764363 |
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