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A study of the effects of photodynamic therapy on the normal tissues of the rabbit jaw.

Photodynamic therapy (PDT) is an anti-cancer treatment which involves the systemic administration of a photosensitising drug which is preferentially absorbed by tumour tissue. Relatively little drug should be absorbed by the surrounding normal tissues. Tumour destruction is achieved when the tumour...

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Detalles Bibliográficos
Autores principales: Meyer, M., Speight, P., Bown, S. G.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1991
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1977877/
https://www.ncbi.nlm.nih.gov/pubmed/1764372
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author Meyer, M.
Speight, P.
Bown, S. G.
author_facet Meyer, M.
Speight, P.
Bown, S. G.
author_sort Meyer, M.
collection PubMed
description Photodynamic therapy (PDT) is an anti-cancer treatment which involves the systemic administration of a photosensitising drug which is preferentially absorbed by tumour tissue. Relatively little drug should be absorbed by the surrounding normal tissues. Tumour destruction is achieved when the tumour is illuminated with light of a wavelength which activates the photosensitising drug thereby inducing a cytotoxic reaction. However studies in many tissues have shown that the hoped for tumour selectivity is rarely achieved. Using the rabbit mandible and gingiva as our models we have studied the effects of various doses of PDT on the tissues of the oral cavity, namely mucosa, bone, muscle and salivary gland. The photosensitiser used was di-sulphonated aluminium phthalocyanine. Results show that whereas bone is extremely resistant to PDT the other tissues are vulnerable to it. In the case of muscle and salivary gland this susceptibility is very much dose related. In salivary tissue necrotising sialometaplasia was observed in areas of the gland adjacent to those that had undergone necrosis. All tissues were noted to heal or regenerate well following PDT injury. IMAGES:
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spelling pubmed-19778772009-09-10 A study of the effects of photodynamic therapy on the normal tissues of the rabbit jaw. Meyer, M. Speight, P. Bown, S. G. Br J Cancer Research Article Photodynamic therapy (PDT) is an anti-cancer treatment which involves the systemic administration of a photosensitising drug which is preferentially absorbed by tumour tissue. Relatively little drug should be absorbed by the surrounding normal tissues. Tumour destruction is achieved when the tumour is illuminated with light of a wavelength which activates the photosensitising drug thereby inducing a cytotoxic reaction. However studies in many tissues have shown that the hoped for tumour selectivity is rarely achieved. Using the rabbit mandible and gingiva as our models we have studied the effects of various doses of PDT on the tissues of the oral cavity, namely mucosa, bone, muscle and salivary gland. The photosensitiser used was di-sulphonated aluminium phthalocyanine. Results show that whereas bone is extremely resistant to PDT the other tissues are vulnerable to it. In the case of muscle and salivary gland this susceptibility is very much dose related. In salivary tissue necrotising sialometaplasia was observed in areas of the gland adjacent to those that had undergone necrosis. All tissues were noted to heal or regenerate well following PDT injury. IMAGES: Nature Publishing Group 1991-12 /pmc/articles/PMC1977877/ /pubmed/1764372 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Meyer, M.
Speight, P.
Bown, S. G.
A study of the effects of photodynamic therapy on the normal tissues of the rabbit jaw.
title A study of the effects of photodynamic therapy on the normal tissues of the rabbit jaw.
title_full A study of the effects of photodynamic therapy on the normal tissues of the rabbit jaw.
title_fullStr A study of the effects of photodynamic therapy on the normal tissues of the rabbit jaw.
title_full_unstemmed A study of the effects of photodynamic therapy on the normal tissues of the rabbit jaw.
title_short A study of the effects of photodynamic therapy on the normal tissues of the rabbit jaw.
title_sort study of the effects of photodynamic therapy on the normal tissues of the rabbit jaw.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1977877/
https://www.ncbi.nlm.nih.gov/pubmed/1764372
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