Rearrangement of chromosome 1p in breast cancer correlates with poor prognostic features.

In a cytogenetic study of breast cancer biopsies, clonal abnormalities of chromosome 1p were identified in 56% (14) of 25 informative patients. Translocations predominated, involving 1p22 (n = 1), 1p35 (n = 1) or 1p36 (n = 10) breakpoints. Chromosome 1p abnormalities were associated with estrogen re...

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Autores principales: Hainsworth, P. J., Raphael, K. L., Stillwell, R. G., Bennett, R. C., Garson, O. M.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1992
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1977890/
https://www.ncbi.nlm.nih.gov/pubmed/1637662
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author Hainsworth, P. J.
Raphael, K. L.
Stillwell, R. G.
Bennett, R. C.
Garson, O. M.
author_facet Hainsworth, P. J.
Raphael, K. L.
Stillwell, R. G.
Bennett, R. C.
Garson, O. M.
author_sort Hainsworth, P. J.
collection PubMed
description In a cytogenetic study of breast cancer biopsies, clonal abnormalities of chromosome 1p were identified in 56% (14) of 25 informative patients. Translocations predominated, involving 1p22 (n = 1), 1p35 (n = 1) or 1p36 (n = 10) breakpoints. Chromosome 1p abnormalities were associated with estrogen receptor (ER) negativity (P = 0.03, 2-tailed Fisher Exact Probability test), high histological grade (P = 0.02, 2-tailed Mann-Whitney U-test) and an unfavourable Melbourne Prognostic Score (NEPA P = 0.02, SEPA P = 0.04, 2-tailed Mann-Whitney U-tests). These findings are consistent with the possibility that a gene located on chromosome 1p is implicated in tumour progression. IMAGES:
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spelling pubmed-19778902009-09-10 Rearrangement of chromosome 1p in breast cancer correlates with poor prognostic features. Hainsworth, P. J. Raphael, K. L. Stillwell, R. G. Bennett, R. C. Garson, O. M. Br J Cancer Research Article In a cytogenetic study of breast cancer biopsies, clonal abnormalities of chromosome 1p were identified in 56% (14) of 25 informative patients. Translocations predominated, involving 1p22 (n = 1), 1p35 (n = 1) or 1p36 (n = 10) breakpoints. Chromosome 1p abnormalities were associated with estrogen receptor (ER) negativity (P = 0.03, 2-tailed Fisher Exact Probability test), high histological grade (P = 0.02, 2-tailed Mann-Whitney U-test) and an unfavourable Melbourne Prognostic Score (NEPA P = 0.02, SEPA P = 0.04, 2-tailed Mann-Whitney U-tests). These findings are consistent with the possibility that a gene located on chromosome 1p is implicated in tumour progression. IMAGES: Nature Publishing Group 1992-07 /pmc/articles/PMC1977890/ /pubmed/1637662 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Hainsworth, P. J.
Raphael, K. L.
Stillwell, R. G.
Bennett, R. C.
Garson, O. M.
Rearrangement of chromosome 1p in breast cancer correlates with poor prognostic features.
title Rearrangement of chromosome 1p in breast cancer correlates with poor prognostic features.
title_full Rearrangement of chromosome 1p in breast cancer correlates with poor prognostic features.
title_fullStr Rearrangement of chromosome 1p in breast cancer correlates with poor prognostic features.
title_full_unstemmed Rearrangement of chromosome 1p in breast cancer correlates with poor prognostic features.
title_short Rearrangement of chromosome 1p in breast cancer correlates with poor prognostic features.
title_sort rearrangement of chromosome 1p in breast cancer correlates with poor prognostic features.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1977890/
https://www.ncbi.nlm.nih.gov/pubmed/1637662
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