Cardiotoxicity of commercial 5-fluorouracil vials stems from the alkaline hydrolysis of this drug.

The cardiotoxicity of 5-fluorouracil (FU) was attributed to impurities present in the injected vials. One of these impurities was identified as fluoroacetaldehyde which is metabolised by isolated perfused rabbit hearts into fluoroacetate (FAC), a highly cardiotoxic compound. FAC was also detected in...

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Autores principales: Lemaire, L., Malet-Martino, M. C., de Forni, M., Martino, R., Lasserre, B.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1992
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1977901/
https://www.ncbi.nlm.nih.gov/pubmed/1637660
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author Lemaire, L.
Malet-Martino, M. C.
de Forni, M.
Martino, R.
Lasserre, B.
author_facet Lemaire, L.
Malet-Martino, M. C.
de Forni, M.
Martino, R.
Lasserre, B.
author_sort Lemaire, L.
collection PubMed
description The cardiotoxicity of 5-fluorouracil (FU) was attributed to impurities present in the injected vials. One of these impurities was identified as fluoroacetaldehyde which is metabolised by isolated perfused rabbit hearts into fluoroacetate (FAC), a highly cardiotoxic compound. FAC was also detected in the urine of patients treated with FU. These impurities were found to be degradation products of FU that are formed in the basic medium employed to dissolve this compound. To avoid chemical degradation of this antineoplastic drug, the solution of FU that will be injected should be prepared immediately before use.
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spelling pubmed-19779012009-09-10 Cardiotoxicity of commercial 5-fluorouracil vials stems from the alkaline hydrolysis of this drug. Lemaire, L. Malet-Martino, M. C. de Forni, M. Martino, R. Lasserre, B. Br J Cancer Research Article The cardiotoxicity of 5-fluorouracil (FU) was attributed to impurities present in the injected vials. One of these impurities was identified as fluoroacetaldehyde which is metabolised by isolated perfused rabbit hearts into fluoroacetate (FAC), a highly cardiotoxic compound. FAC was also detected in the urine of patients treated with FU. These impurities were found to be degradation products of FU that are formed in the basic medium employed to dissolve this compound. To avoid chemical degradation of this antineoplastic drug, the solution of FU that will be injected should be prepared immediately before use. Nature Publishing Group 1992-07 /pmc/articles/PMC1977901/ /pubmed/1637660 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Lemaire, L.
Malet-Martino, M. C.
de Forni, M.
Martino, R.
Lasserre, B.
Cardiotoxicity of commercial 5-fluorouracil vials stems from the alkaline hydrolysis of this drug.
title Cardiotoxicity of commercial 5-fluorouracil vials stems from the alkaline hydrolysis of this drug.
title_full Cardiotoxicity of commercial 5-fluorouracil vials stems from the alkaline hydrolysis of this drug.
title_fullStr Cardiotoxicity of commercial 5-fluorouracil vials stems from the alkaline hydrolysis of this drug.
title_full_unstemmed Cardiotoxicity of commercial 5-fluorouracil vials stems from the alkaline hydrolysis of this drug.
title_short Cardiotoxicity of commercial 5-fluorouracil vials stems from the alkaline hydrolysis of this drug.
title_sort cardiotoxicity of commercial 5-fluorouracil vials stems from the alkaline hydrolysis of this drug.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1977901/
https://www.ncbi.nlm.nih.gov/pubmed/1637660
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