Role of cholecystokinin in dietary fat-promoted azaserine-induced pancreatic carcinogenesis in rats.

The role of cholecystokinin in dietary fat-promoted pancreatic carcinogenesis was investigated in azaserine-treated rats, using lorglumide, a highly specific cholecystokinin-receptor antagonist. The animals were killed 8 months after the start of treatment. Cholecystokinin, but not dietary unsaturat...

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Autores principales: Appel, M. J., Meijers, M., Van Garderen-Hoetmer, A., Lamers, C. B., Rovati, L. C., Sprij-Mooij, D., Jansen, J. B., Woutersen, R. A.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1992
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1977907/
https://www.ncbi.nlm.nih.gov/pubmed/1637675
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author Appel, M. J.
Meijers, M.
Van Garderen-Hoetmer, A.
Lamers, C. B.
Rovati, L. C.
Sprij-Mooij, D.
Jansen, J. B.
Woutersen, R. A.
author_facet Appel, M. J.
Meijers, M.
Van Garderen-Hoetmer, A.
Lamers, C. B.
Rovati, L. C.
Sprij-Mooij, D.
Jansen, J. B.
Woutersen, R. A.
author_sort Appel, M. J.
collection PubMed
description The role of cholecystokinin in dietary fat-promoted pancreatic carcinogenesis was investigated in azaserine-treated rats, using lorglumide, a highly specific cholecystokinin-receptor antagonist. The animals were killed 8 months after the start of treatment. Cholecystokinin, but not dietary unsaturated fat, increased pancreatic weight. Rats treated with cholecystokinin developed more acidophilic atypical acinar cell nodules, adenomas and adenocarcinomas than control animals. Rats maintained on the high-fat diet developed significantly more adenomas and adenocarcinomas than controls given a diet low in unsaturated fat. Lorglumide largely inhibited the enhancing effect of cholecystokinin, but not of dietary fat, on pancreatic carcinogenesis indicating that it is unlikely that the promoting effect of dietary unsaturated fat on pancreatic carcinogenesis is mediated via cholecystokinin.
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spelling pubmed-19779072009-09-10 Role of cholecystokinin in dietary fat-promoted azaserine-induced pancreatic carcinogenesis in rats. Appel, M. J. Meijers, M. Van Garderen-Hoetmer, A. Lamers, C. B. Rovati, L. C. Sprij-Mooij, D. Jansen, J. B. Woutersen, R. A. Br J Cancer Research Article The role of cholecystokinin in dietary fat-promoted pancreatic carcinogenesis was investigated in azaserine-treated rats, using lorglumide, a highly specific cholecystokinin-receptor antagonist. The animals were killed 8 months after the start of treatment. Cholecystokinin, but not dietary unsaturated fat, increased pancreatic weight. Rats treated with cholecystokinin developed more acidophilic atypical acinar cell nodules, adenomas and adenocarcinomas than control animals. Rats maintained on the high-fat diet developed significantly more adenomas and adenocarcinomas than controls given a diet low in unsaturated fat. Lorglumide largely inhibited the enhancing effect of cholecystokinin, but not of dietary fat, on pancreatic carcinogenesis indicating that it is unlikely that the promoting effect of dietary unsaturated fat on pancreatic carcinogenesis is mediated via cholecystokinin. Nature Publishing Group 1992-07 /pmc/articles/PMC1977907/ /pubmed/1637675 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Appel, M. J.
Meijers, M.
Van Garderen-Hoetmer, A.
Lamers, C. B.
Rovati, L. C.
Sprij-Mooij, D.
Jansen, J. B.
Woutersen, R. A.
Role of cholecystokinin in dietary fat-promoted azaserine-induced pancreatic carcinogenesis in rats.
title Role of cholecystokinin in dietary fat-promoted azaserine-induced pancreatic carcinogenesis in rats.
title_full Role of cholecystokinin in dietary fat-promoted azaserine-induced pancreatic carcinogenesis in rats.
title_fullStr Role of cholecystokinin in dietary fat-promoted azaserine-induced pancreatic carcinogenesis in rats.
title_full_unstemmed Role of cholecystokinin in dietary fat-promoted azaserine-induced pancreatic carcinogenesis in rats.
title_short Role of cholecystokinin in dietary fat-promoted azaserine-induced pancreatic carcinogenesis in rats.
title_sort role of cholecystokinin in dietary fat-promoted azaserine-induced pancreatic carcinogenesis in rats.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1977907/
https://www.ncbi.nlm.nih.gov/pubmed/1637675
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