Chlorambucil-monoglutathionyl conjugate is sequestered by human alpha class glutathione S-transferases.

The spontaneous reaction of 110 microM chlorambucil (4-[p-[bis(2-chloroethyl)amino]phenyl]-butanoic acid; CHB) with 5 mM GSH at 37 degrees C in physiological phosphate-buffered saline for 35 min gave primarily the monoglutathionyl derivative, 4-[p-[N-2-chloroethyl,N-2-S-glutathionylethyl]amino]pheny...

Descripción completa

Detalles Bibliográficos
Autores principales: Meyer, D. J., Gilmore, K. S., Harris, J. M., Hartley, J. A., Ketterer, B.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1992
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1977928/
https://www.ncbi.nlm.nih.gov/pubmed/1520581

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1977928/
https://www.ncbi.nlm.nih.gov/pubmed/1520581

Ejemplares similares