Cancer mortality in the first degree relatives of young breast cancer patients.

In a retrospective cohort study, the mothers and sisters of 740 breast cancer patients aged under 36 at diagnosis have been studied for mortality and cancer incidence. Significantly increased breast cancer mortality was observed below age 60 (30 deaths; SMR = 3.4), but not at older ages (four deaths...

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Autores principales: Anderson, K. E., Easton, D. F., Matthews, F. E., Peto, J.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1992
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1977943/
https://www.ncbi.nlm.nih.gov/pubmed/1520598
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author Anderson, K. E.
Easton, D. F.
Matthews, F. E.
Peto, J.
author_facet Anderson, K. E.
Easton, D. F.
Matthews, F. E.
Peto, J.
author_sort Anderson, K. E.
collection PubMed
description In a retrospective cohort study, the mothers and sisters of 740 breast cancer patients aged under 36 at diagnosis have been studied for mortality and cancer incidence. Significantly increased breast cancer mortality was observed below age 60 (30 deaths; SMR = 3.4), but not at older ages (four deaths; SMR = 0.9). The cumulative breast cancer incidence in the relatives was 3.6% by age 50, 7.6% by age 60 and 11.6% by age 70. They also suffered excess mortality below age 60 for cancers of reproductive sites (cervix, ovary and endometrium; 15 deaths; SMR = 2.6) and lung (11 deaths; SMR = 3.2), but not for other sites (12 deaths; SMR = 0.9). This large population-based cohort study provides further confirmation of genetic susceptibility to breast cancer at young ages.
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spelling pubmed-19779432009-09-10 Cancer mortality in the first degree relatives of young breast cancer patients. Anderson, K. E. Easton, D. F. Matthews, F. E. Peto, J. Br J Cancer Research Article In a retrospective cohort study, the mothers and sisters of 740 breast cancer patients aged under 36 at diagnosis have been studied for mortality and cancer incidence. Significantly increased breast cancer mortality was observed below age 60 (30 deaths; SMR = 3.4), but not at older ages (four deaths; SMR = 0.9). The cumulative breast cancer incidence in the relatives was 3.6% by age 50, 7.6% by age 60 and 11.6% by age 70. They also suffered excess mortality below age 60 for cancers of reproductive sites (cervix, ovary and endometrium; 15 deaths; SMR = 2.6) and lung (11 deaths; SMR = 3.2), but not for other sites (12 deaths; SMR = 0.9). This large population-based cohort study provides further confirmation of genetic susceptibility to breast cancer at young ages. Nature Publishing Group 1992-09 /pmc/articles/PMC1977943/ /pubmed/1520598 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Anderson, K. E.
Easton, D. F.
Matthews, F. E.
Peto, J.
Cancer mortality in the first degree relatives of young breast cancer patients.
title Cancer mortality in the first degree relatives of young breast cancer patients.
title_full Cancer mortality in the first degree relatives of young breast cancer patients.
title_fullStr Cancer mortality in the first degree relatives of young breast cancer patients.
title_full_unstemmed Cancer mortality in the first degree relatives of young breast cancer patients.
title_short Cancer mortality in the first degree relatives of young breast cancer patients.
title_sort cancer mortality in the first degree relatives of young breast cancer patients.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1977943/
https://www.ncbi.nlm.nih.gov/pubmed/1520598
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