Tumour-associated hypoglycaemia in a murine cachexia model.

Animals bearing a cachexia-inducing tumour, the MAC16 adenocarcinoma, showed a progressive decrease in blood glucose levels with increasing weight loss, while animals bearing a histologically similar tumour, the MAC13 adenocarcinoma, showed no change in either body weight or blood glucose levels wit...

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Detalles Bibliográficos
Autores principales: McDevitt, T. M., Tisdale, M. J.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1992
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1977981/
https://www.ncbi.nlm.nih.gov/pubmed/1358167
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author McDevitt, T. M.
Tisdale, M. J.
author_facet McDevitt, T. M.
Tisdale, M. J.
author_sort McDevitt, T. M.
collection PubMed
description Animals bearing a cachexia-inducing tumour, the MAC16 adenocarcinoma, showed a progressive decrease in blood glucose levels with increasing weight loss, while animals bearing a histologically similar tumour, the MAC13 adenocarcinoma, showed no change in either body weight or blood glucose levels with growth of the tumour. The effect of the MAC16 tumour on blood glucose levels appeared to be unrelated to food intake, glucose consumption by the tumour, or to the production of increased levels of IGF-I and IGF-II mRNA by the tumour cells. The relationship between the induction of cachexia and alteration in blood glucose levels remains unknown. IMAGES:
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spelling pubmed-19779812009-09-10 Tumour-associated hypoglycaemia in a murine cachexia model. McDevitt, T. M. Tisdale, M. J. Br J Cancer Research Article Animals bearing a cachexia-inducing tumour, the MAC16 adenocarcinoma, showed a progressive decrease in blood glucose levels with increasing weight loss, while animals bearing a histologically similar tumour, the MAC13 adenocarcinoma, showed no change in either body weight or blood glucose levels with growth of the tumour. The effect of the MAC16 tumour on blood glucose levels appeared to be unrelated to food intake, glucose consumption by the tumour, or to the production of increased levels of IGF-I and IGF-II mRNA by the tumour cells. The relationship between the induction of cachexia and alteration in blood glucose levels remains unknown. IMAGES: Nature Publishing Group 1992-11 /pmc/articles/PMC1977981/ /pubmed/1358167 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
McDevitt, T. M.
Tisdale, M. J.
Tumour-associated hypoglycaemia in a murine cachexia model.
title Tumour-associated hypoglycaemia in a murine cachexia model.
title_full Tumour-associated hypoglycaemia in a murine cachexia model.
title_fullStr Tumour-associated hypoglycaemia in a murine cachexia model.
title_full_unstemmed Tumour-associated hypoglycaemia in a murine cachexia model.
title_short Tumour-associated hypoglycaemia in a murine cachexia model.
title_sort tumour-associated hypoglycaemia in a murine cachexia model.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1977981/
https://www.ncbi.nlm.nih.gov/pubmed/1358167
work_keys_str_mv AT mcdevitttm tumourassociatedhypoglycaemiainamurinecachexiamodel
AT tisdalemj tumourassociatedhypoglycaemiainamurinecachexiamodel

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