Oestrogen receptor protein and mRNA in adenocarcinoma of the uterine cervix.

We have investigated the oestrogen receptor (ER) status of 20 cervical adenocarcinomas by immunocytochemistry for ER protein and non-isotopic in situ hybridisation for ER mRNA. Both methods, which are applicable to paraffin sections, were developed and validated in breast carcinomas with known ER co...

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Autores principales: Ismail, S. M., Thomas, G. A., Ghandour, F. A., Davies, H. G., Attanoos, R., Williams, E. D.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1992
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1978005/
https://www.ncbi.nlm.nih.gov/pubmed/1457356
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author Ismail, S. M.
Thomas, G. A.
Ghandour, F. A.
Davies, H. G.
Attanoos, R.
Williams, E. D.
author_facet Ismail, S. M.
Thomas, G. A.
Ghandour, F. A.
Davies, H. G.
Attanoos, R.
Williams, E. D.
author_sort Ismail, S. M.
collection PubMed
description We have investigated the oestrogen receptor (ER) status of 20 cervical adenocarcinomas by immunocytochemistry for ER protein and non-isotopic in situ hybridisation for ER mRNA. Both methods, which are applicable to paraffin sections, were developed and validated in breast carcinomas with known ER content. Six cervical adenocarcinomas contained immunocytochemically demonstrable ER protein; all contained ER mRNA, but staining was less intense in poorly differentiated areas of four tumours. This disparity between protein and mRNA detection needs further investigation as does the possibility that oestrogens may play a role in the pathogenesis of cervical adenocarcinoma. IMAGES:
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spelling pubmed-19780052009-09-10 Oestrogen receptor protein and mRNA in adenocarcinoma of the uterine cervix. Ismail, S. M. Thomas, G. A. Ghandour, F. A. Davies, H. G. Attanoos, R. Williams, E. D. Br J Cancer Research Article We have investigated the oestrogen receptor (ER) status of 20 cervical adenocarcinomas by immunocytochemistry for ER protein and non-isotopic in situ hybridisation for ER mRNA. Both methods, which are applicable to paraffin sections, were developed and validated in breast carcinomas with known ER content. Six cervical adenocarcinomas contained immunocytochemically demonstrable ER protein; all contained ER mRNA, but staining was less intense in poorly differentiated areas of four tumours. This disparity between protein and mRNA detection needs further investigation as does the possibility that oestrogens may play a role in the pathogenesis of cervical adenocarcinoma. IMAGES: Nature Publishing Group 1992-12 /pmc/articles/PMC1978005/ /pubmed/1457356 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Ismail, S. M.
Thomas, G. A.
Ghandour, F. A.
Davies, H. G.
Attanoos, R.
Williams, E. D.
Oestrogen receptor protein and mRNA in adenocarcinoma of the uterine cervix.
title Oestrogen receptor protein and mRNA in adenocarcinoma of the uterine cervix.
title_full Oestrogen receptor protein and mRNA in adenocarcinoma of the uterine cervix.
title_fullStr Oestrogen receptor protein and mRNA in adenocarcinoma of the uterine cervix.
title_full_unstemmed Oestrogen receptor protein and mRNA in adenocarcinoma of the uterine cervix.
title_short Oestrogen receptor protein and mRNA in adenocarcinoma of the uterine cervix.
title_sort oestrogen receptor protein and mrna in adenocarcinoma of the uterine cervix.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1978005/
https://www.ncbi.nlm.nih.gov/pubmed/1457356
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