Expression of the ERBB3 gene product in breast cancer.

Abnormalities of the EGF receptor and/or the related ERBB2 receptor occur in a significant proportion of cases of human breast cancer and are important influences in the behaviour of this tumour type. In this report we demonstrate by nucleic acid analysis and immunohistochemistry that the recently r...

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Autores principales: Lemoine, N. R., Barnes, D. M., Hollywood, D. P., Hughes, C. M., Smith, P., Dublin, E., Prigent, S. A., Gullick, W. J., Hurst, H. C.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1992
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1978009/
https://www.ncbi.nlm.nih.gov/pubmed/1333787
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author Lemoine, N. R.
Barnes, D. M.
Hollywood, D. P.
Hughes, C. M.
Smith, P.
Dublin, E.
Prigent, S. A.
Gullick, W. J.
Hurst, H. C.
author_facet Lemoine, N. R.
Barnes, D. M.
Hollywood, D. P.
Hughes, C. M.
Smith, P.
Dublin, E.
Prigent, S. A.
Gullick, W. J.
Hurst, H. C.
author_sort Lemoine, N. R.
collection PubMed
description Abnormalities of the EGF receptor and/or the related ERBB2 receptor occur in a significant proportion of cases of human breast cancer and are important influences in the behaviour of this tumour type. In this report we demonstrate by nucleic acid analysis and immunohistochemistry that the recently recognised third member of this gene family, ERBB3, shows a wide range of expression in breast cancer, and shows stronger immunoreactivity than that observed in normal tissue in 43 out of 195 cases (22%) of primary breast cancer. Overexpression of ERBB3 appears to result from increased levels of gene transcription since in none of the cell lines or primary cancers analysed did we find evidence of gene amplification. High expression of ERBB3 is positively associated with the presence of lymph node metastases, but there was no demonstrable relationship with patient survival in this series. IMAGES:
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spelling pubmed-19780092009-09-10 Expression of the ERBB3 gene product in breast cancer. Lemoine, N. R. Barnes, D. M. Hollywood, D. P. Hughes, C. M. Smith, P. Dublin, E. Prigent, S. A. Gullick, W. J. Hurst, H. C. Br J Cancer Research Article Abnormalities of the EGF receptor and/or the related ERBB2 receptor occur in a significant proportion of cases of human breast cancer and are important influences in the behaviour of this tumour type. In this report we demonstrate by nucleic acid analysis and immunohistochemistry that the recently recognised third member of this gene family, ERBB3, shows a wide range of expression in breast cancer, and shows stronger immunoreactivity than that observed in normal tissue in 43 out of 195 cases (22%) of primary breast cancer. Overexpression of ERBB3 appears to result from increased levels of gene transcription since in none of the cell lines or primary cancers analysed did we find evidence of gene amplification. High expression of ERBB3 is positively associated with the presence of lymph node metastases, but there was no demonstrable relationship with patient survival in this series. IMAGES: Nature Publishing Group 1992-12 /pmc/articles/PMC1978009/ /pubmed/1333787 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Lemoine, N. R.
Barnes, D. M.
Hollywood, D. P.
Hughes, C. M.
Smith, P.
Dublin, E.
Prigent, S. A.
Gullick, W. J.
Hurst, H. C.
Expression of the ERBB3 gene product in breast cancer.
title Expression of the ERBB3 gene product in breast cancer.
title_full Expression of the ERBB3 gene product in breast cancer.
title_fullStr Expression of the ERBB3 gene product in breast cancer.
title_full_unstemmed Expression of the ERBB3 gene product in breast cancer.
title_short Expression of the ERBB3 gene product in breast cancer.
title_sort expression of the erbb3 gene product in breast cancer.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1978009/
https://www.ncbi.nlm.nih.gov/pubmed/1333787
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