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Chromosomal localisation of two putative 11p oncosuppressor genes involved in human ovarian tumours.

In this study, 44 primary or metastatic human ovarian tumours were tested for allelic deletions on the short arm of chromosome 11. Analysis of 12 polymorphic loci by Southern blotting evidenced loss of heterozygosity (LOH) in at least one locus in 41% of cases. Moreover, two hot spots of deletions w...

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Autores principales: Viel, A., Giannini, F., Tumiotto, L., Sopracordevole, F., Visentin, M. C., Boiocchi, M.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1992
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1978017/
https://www.ncbi.nlm.nih.gov/pubmed/1360809
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author Viel, A.
Giannini, F.
Tumiotto, L.
Sopracordevole, F.
Visentin, M. C.
Boiocchi, M.
author_facet Viel, A.
Giannini, F.
Tumiotto, L.
Sopracordevole, F.
Visentin, M. C.
Boiocchi, M.
author_sort Viel, A.
collection PubMed
description In this study, 44 primary or metastatic human ovarian tumours were tested for allelic deletions on the short arm of chromosome 11. Analysis of 12 polymorphic loci by Southern blotting evidenced loss of heterozygosity (LOH) in at least one locus in 41% of cases. Moreover, two hot spots of deletions were tentatively mapped on 11p13 and 11p15.5. Our results demonstrated that LOH at 11p is a common event in ovarian carcinomas and were indicative of the possible existence in 11p of two oncosuppressor genes involved in ovarian carcinogenesis. The similarity observed with 11p allelic losses in Wilms tumours, clustered in 11p13 and 11p15.5 too, suggests that deletion and possibly inactivation of the same growth regulatory genes (WT genes) could also contribute to development of the malignant phenotype in ovarian carcinomas. Finally, a statistically significant association (P = 0.005) between 11p deletions and hepatic involvement was suggested by the analysis of distribution of 11p LOH relative to different clinical and pathological parameters of the tumour patients. IMAGES:
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spelling pubmed-19780172009-09-10 Chromosomal localisation of two putative 11p oncosuppressor genes involved in human ovarian tumours. Viel, A. Giannini, F. Tumiotto, L. Sopracordevole, F. Visentin, M. C. Boiocchi, M. Br J Cancer Research Article In this study, 44 primary or metastatic human ovarian tumours were tested for allelic deletions on the short arm of chromosome 11. Analysis of 12 polymorphic loci by Southern blotting evidenced loss of heterozygosity (LOH) in at least one locus in 41% of cases. Moreover, two hot spots of deletions were tentatively mapped on 11p13 and 11p15.5. Our results demonstrated that LOH at 11p is a common event in ovarian carcinomas and were indicative of the possible existence in 11p of two oncosuppressor genes involved in ovarian carcinogenesis. The similarity observed with 11p allelic losses in Wilms tumours, clustered in 11p13 and 11p15.5 too, suggests that deletion and possibly inactivation of the same growth regulatory genes (WT genes) could also contribute to development of the malignant phenotype in ovarian carcinomas. Finally, a statistically significant association (P = 0.005) between 11p deletions and hepatic involvement was suggested by the analysis of distribution of 11p LOH relative to different clinical and pathological parameters of the tumour patients. IMAGES: Nature Publishing Group 1992-12 /pmc/articles/PMC1978017/ /pubmed/1360809 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Viel, A.
Giannini, F.
Tumiotto, L.
Sopracordevole, F.
Visentin, M. C.
Boiocchi, M.
Chromosomal localisation of two putative 11p oncosuppressor genes involved in human ovarian tumours.
title Chromosomal localisation of two putative 11p oncosuppressor genes involved in human ovarian tumours.
title_full Chromosomal localisation of two putative 11p oncosuppressor genes involved in human ovarian tumours.
title_fullStr Chromosomal localisation of two putative 11p oncosuppressor genes involved in human ovarian tumours.
title_full_unstemmed Chromosomal localisation of two putative 11p oncosuppressor genes involved in human ovarian tumours.
title_short Chromosomal localisation of two putative 11p oncosuppressor genes involved in human ovarian tumours.
title_sort chromosomal localisation of two putative 11p oncosuppressor genes involved in human ovarian tumours.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1978017/
https://www.ncbi.nlm.nih.gov/pubmed/1360809
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