Peripheral blood lymphocyte number and phenotype prior to therapy correlate with response in subcutaneously applied rIL-2 therapy of renal cell carcinoma.

The phenotype of peripheral blood lymphocytes of 27 renal cell carcinoma patients before and at the end of subcutaneously given rIL-2 therapy was determined by two colour flow cytometry. Therapy induced changes in peripheral blood leucocyte composition and phenotypes were comparable to those reporte...

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Autores principales: Janssen, R. A., Sleijfer, D. T., Heijn, A. A., Mulder, N. H., The, T. H., de Leij, L.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1992
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1978045/
https://www.ncbi.nlm.nih.gov/pubmed/1457361
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author Janssen, R. A.
Sleijfer, D. T.
Heijn, A. A.
Mulder, N. H.
The, T. H.
de Leij, L.
author_facet Janssen, R. A.
Sleijfer, D. T.
Heijn, A. A.
Mulder, N. H.
The, T. H.
de Leij, L.
author_sort Janssen, R. A.
collection PubMed
description The phenotype of peripheral blood lymphocytes of 27 renal cell carcinoma patients before and at the end of subcutaneously given rIL-2 therapy was determined by two colour flow cytometry. Therapy induced changes in peripheral blood leucocyte composition and phenotypes were comparable to those reported for intravenously given rIL-2. The present paper shows a correlation between the 'activation status' of the patient before therapy and eventual response.
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spelling pubmed-19780452009-09-10 Peripheral blood lymphocyte number and phenotype prior to therapy correlate with response in subcutaneously applied rIL-2 therapy of renal cell carcinoma. Janssen, R. A. Sleijfer, D. T. Heijn, A. A. Mulder, N. H. The, T. H. de Leij, L. Br J Cancer Research Article The phenotype of peripheral blood lymphocytes of 27 renal cell carcinoma patients before and at the end of subcutaneously given rIL-2 therapy was determined by two colour flow cytometry. Therapy induced changes in peripheral blood leucocyte composition and phenotypes were comparable to those reported for intravenously given rIL-2. The present paper shows a correlation between the 'activation status' of the patient before therapy and eventual response. Nature Publishing Group 1992-12 /pmc/articles/PMC1978045/ /pubmed/1457361 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Janssen, R. A.
Sleijfer, D. T.
Heijn, A. A.
Mulder, N. H.
The, T. H.
de Leij, L.
Peripheral blood lymphocyte number and phenotype prior to therapy correlate with response in subcutaneously applied rIL-2 therapy of renal cell carcinoma.
title Peripheral blood lymphocyte number and phenotype prior to therapy correlate with response in subcutaneously applied rIL-2 therapy of renal cell carcinoma.
title_full Peripheral blood lymphocyte number and phenotype prior to therapy correlate with response in subcutaneously applied rIL-2 therapy of renal cell carcinoma.
title_fullStr Peripheral blood lymphocyte number and phenotype prior to therapy correlate with response in subcutaneously applied rIL-2 therapy of renal cell carcinoma.
title_full_unstemmed Peripheral blood lymphocyte number and phenotype prior to therapy correlate with response in subcutaneously applied rIL-2 therapy of renal cell carcinoma.
title_short Peripheral blood lymphocyte number and phenotype prior to therapy correlate with response in subcutaneously applied rIL-2 therapy of renal cell carcinoma.
title_sort peripheral blood lymphocyte number and phenotype prior to therapy correlate with response in subcutaneously applied ril-2 therapy of renal cell carcinoma.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1978045/
https://www.ncbi.nlm.nih.gov/pubmed/1457361
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