Pixel-to-pixel correlation between images of absolute ATP concentrations and blood flow in tumours.

Iodo(14C-)antipyrine autoradiography and imaging bioluminescence have been combined to obtain pixel-to-pixel correlations between absolute values for local blood flow and ATP concentrations at a microscopical level within designated areas in hamster melanomas. Positive pixel-to-pixel correlations we...

Descripción completa

Detalles Bibliográficos
Autores principales: Walenta, S., Dellian, M., Goetz, A. E., Kuhnle, G. E., Mueller-Klieser, W.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1992
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1978060/
https://www.ncbi.nlm.nih.gov/pubmed/1457351
_version_ 1782135396352655360
author Walenta, S.
Dellian, M.
Goetz, A. E.
Kuhnle, G. E.
Mueller-Klieser, W.
author_facet Walenta, S.
Dellian, M.
Goetz, A. E.
Kuhnle, G. E.
Mueller-Klieser, W.
author_sort Walenta, S.
collection PubMed
description Iodo(14C-)antipyrine autoradiography and imaging bioluminescence have been combined to obtain pixel-to-pixel correlations between absolute values for local blood flow and ATP concentrations at a microscopical level within designated areas in hamster melanomas. Positive pixel-to-pixel correlations were obtained in 4 of 6 tumours. Both flow and ATP values were less in mostly necrotic than in mostly viable tumour regions. The data provide evidence for the energetic state of cancer cells being strongly influenced by the efficiency of tumour microcirculation in several but not in all malignancies investigated. IMAGES:
format Text
id pubmed-1978060
institution National Center for Biotechnology Information
language English
publishDate 1992
publisher Nature Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-19780602009-09-10 Pixel-to-pixel correlation between images of absolute ATP concentrations and blood flow in tumours. Walenta, S. Dellian, M. Goetz, A. E. Kuhnle, G. E. Mueller-Klieser, W. Br J Cancer Research Article Iodo(14C-)antipyrine autoradiography and imaging bioluminescence have been combined to obtain pixel-to-pixel correlations between absolute values for local blood flow and ATP concentrations at a microscopical level within designated areas in hamster melanomas. Positive pixel-to-pixel correlations were obtained in 4 of 6 tumours. Both flow and ATP values were less in mostly necrotic than in mostly viable tumour regions. The data provide evidence for the energetic state of cancer cells being strongly influenced by the efficiency of tumour microcirculation in several but not in all malignancies investigated. IMAGES: Nature Publishing Group 1992-12 /pmc/articles/PMC1978060/ /pubmed/1457351 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Walenta, S.
Dellian, M.
Goetz, A. E.
Kuhnle, G. E.
Mueller-Klieser, W.
Pixel-to-pixel correlation between images of absolute ATP concentrations and blood flow in tumours.
title Pixel-to-pixel correlation between images of absolute ATP concentrations and blood flow in tumours.
title_full Pixel-to-pixel correlation between images of absolute ATP concentrations and blood flow in tumours.
title_fullStr Pixel-to-pixel correlation between images of absolute ATP concentrations and blood flow in tumours.
title_full_unstemmed Pixel-to-pixel correlation between images of absolute ATP concentrations and blood flow in tumours.
title_short Pixel-to-pixel correlation between images of absolute ATP concentrations and blood flow in tumours.
title_sort pixel-to-pixel correlation between images of absolute atp concentrations and blood flow in tumours.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1978060/
https://www.ncbi.nlm.nih.gov/pubmed/1457351
work_keys_str_mv AT walentas pixeltopixelcorrelationbetweenimagesofabsoluteatpconcentrationsandbloodflowintumours
AT dellianm pixeltopixelcorrelationbetweenimagesofabsoluteatpconcentrationsandbloodflowintumours
AT goetzae pixeltopixelcorrelationbetweenimagesofabsoluteatpconcentrationsandbloodflowintumours
AT kuhnlege pixeltopixelcorrelationbetweenimagesofabsoluteatpconcentrationsandbloodflowintumours
AT muellerklieserw pixeltopixelcorrelationbetweenimagesofabsoluteatpconcentrationsandbloodflowintumours

Ejemplares similares