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Subclinical sympathetic neuropathy appears early in the course of Crohn's disease

BACKGROUND: We have previously demonstrated that patients with Crohn's disease (CD) of long duration have signs of autonomic neuropathy. The aim of this study was to examine whether autonomic neuropathy is an early manifestation of CD, or a sign appearing late in the course. METHODS: Twenty pat...

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Autores principales: Ohlsson, Bodil, Sundkvist, Göran, Lindgren, Stefan
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2007
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1978494/
https://www.ncbi.nlm.nih.gov/pubmed/17697346
http://dx.doi.org/10.1186/1471-230X-7-33
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author Ohlsson, Bodil
Sundkvist, Göran
Lindgren, Stefan
author_facet Ohlsson, Bodil
Sundkvist, Göran
Lindgren, Stefan
author_sort Ohlsson, Bodil
collection PubMed
description BACKGROUND: We have previously demonstrated that patients with Crohn's disease (CD) of long duration have signs of autonomic neuropathy. The aim of this study was to examine whether autonomic neuropathy is an early manifestation of CD, or a sign appearing late in the course. METHODS: Twenty patients, median age 40 years, with a short duration of CD were included. Examination of autonomic reflexes included heart rate reaction to tilt (acceleration index – AI, brake index – BI) and heart rate variation to deep-breathing (expiration/inspiration index-E/I). Seven years later the same examinations were repeated, and in addition we examined the vasoconstriction response to indirect cooling by laser Doppler (vasoconstriction-index – VAC-index). The results were compared with healthy individuals. RESULTS: There was no difference in the blood pressure between controls and the patients with CD at rest, but eight minutes after tilt, the systolic blood pressure was lowered in patients compared to controls, both at the first assessment (p = 0.016) and after seven years (p = 0.042). The change in systolic blood pressure between rest and eight minutes after tilt was not significant at the first assessment, while a significant change compared to controls was observed seven years later (p = 0.028). This indicates a progressive dysfunction. There were no differences in E/I, AI, BI or VAC indexes between patients and controls. CONCLUSION: Patients with CD suffer from autonomic neuropathy early in their disease, suggesting involvement of many different organ systems in this entity.
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spelling pubmed-19784942007-09-19 Subclinical sympathetic neuropathy appears early in the course of Crohn's disease Ohlsson, Bodil Sundkvist, Göran Lindgren, Stefan BMC Gastroenterol Research Article BACKGROUND: We have previously demonstrated that patients with Crohn's disease (CD) of long duration have signs of autonomic neuropathy. The aim of this study was to examine whether autonomic neuropathy is an early manifestation of CD, or a sign appearing late in the course. METHODS: Twenty patients, median age 40 years, with a short duration of CD were included. Examination of autonomic reflexes included heart rate reaction to tilt (acceleration index – AI, brake index – BI) and heart rate variation to deep-breathing (expiration/inspiration index-E/I). Seven years later the same examinations were repeated, and in addition we examined the vasoconstriction response to indirect cooling by laser Doppler (vasoconstriction-index – VAC-index). The results were compared with healthy individuals. RESULTS: There was no difference in the blood pressure between controls and the patients with CD at rest, but eight minutes after tilt, the systolic blood pressure was lowered in patients compared to controls, both at the first assessment (p = 0.016) and after seven years (p = 0.042). The change in systolic blood pressure between rest and eight minutes after tilt was not significant at the first assessment, while a significant change compared to controls was observed seven years later (p = 0.028). This indicates a progressive dysfunction. There were no differences in E/I, AI, BI or VAC indexes between patients and controls. CONCLUSION: Patients with CD suffer from autonomic neuropathy early in their disease, suggesting involvement of many different organ systems in this entity. BioMed Central 2007-08-14 /pmc/articles/PMC1978494/ /pubmed/17697346 http://dx.doi.org/10.1186/1471-230X-7-33 Text en Copyright © 2007 Ohlsson et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Ohlsson, Bodil
Sundkvist, Göran
Lindgren, Stefan
Subclinical sympathetic neuropathy appears early in the course of Crohn's disease
title Subclinical sympathetic neuropathy appears early in the course of Crohn's disease
title_full Subclinical sympathetic neuropathy appears early in the course of Crohn's disease
title_fullStr Subclinical sympathetic neuropathy appears early in the course of Crohn's disease
title_full_unstemmed Subclinical sympathetic neuropathy appears early in the course of Crohn's disease
title_short Subclinical sympathetic neuropathy appears early in the course of Crohn's disease
title_sort subclinical sympathetic neuropathy appears early in the course of crohn's disease
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1978494/
https://www.ncbi.nlm.nih.gov/pubmed/17697346
http://dx.doi.org/10.1186/1471-230X-7-33
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