Cargando…

Genome bioinformatic analysis of nonsynonymous SNPs

BACKGROUND: Genome-wide association studies of common diseases for common, low penetrance causal variants are underway. A proportion of these will alter protein sequences, the most common of which is the non-synonymous single nucleotide polymorphism (nsSNP). It would be an advantage if the functiona...

Descripción completa

Detalles Bibliográficos
Autores principales:	Burke, David F, Worth, Catherine L, Priego, Eva-Maria, Cheng, Tammy, Smink, Luc J, Todd, John A, Blundell, Tom L
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2007
Materias:	Methodology Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1978506/ https://www.ncbi.nlm.nih.gov/pubmed/17708757 http://dx.doi.org/10.1186/1471-2105-8-301

Ejemplares similares

EFIN: predicting the functional impact of nonsynonymous single nucleotide polymorphisms in human genome
por: Zeng, Shuai, et al.
Publicado: (2014)

Sequence and structure based assessment of nonsynonymous SNPs in hypertrichosis universalis
por: Waheed, Rabiya, et al.
Publicado: (2012)

Loss and Gain of Human Acidic Mammalian Chitinase Activity by Nonsynonymous SNPs
por: Okawa, Kazuaki, et al.
Publicado: (2016)

Scrutinizing Deleterious Nonsynonymous SNPs and Their Effect on Human POLD1 Gene
por: Bappy, Md. Nazmul Islam, et al.
Publicado: (2022)

Genetic basis of common human disease: insight into the role of nonsynonymous SNPs from genome-wide association studies
por: Pal, Lipika R, et al.
Publicado: (2011)

dbNSFP: A Lightweight Database of Human Nonsynonymous SNPs and Their Functional Predictions
por: Liu, Xiaoming, et al.
Publicado: (2011)

Insilico prediction and functional analysis of nonsynonymous SNPs in human CTLA4 gene
por: Irfan, Muhammad, et al.
Publicado: (2022)

Whole-genome resequencing shows numerous genes with nonsynonymous SNPs in the Japanese native cattle Kuchinoshima-Ushi
por: Kawahara-Miki, Ryouka, et al.
Publicado: (2011)

A comprehensive in silico analysis of the deleterious nonsynonymous SNPs of human FOXP2 protein
por: Akter, Mahmuda, et al.
Publicado: (2022)

Dynamic insights into the effects of nonsynonymous polymorphisms (nsSNPs) on loss of TREM2 function
por: Dash, Raju, et al.
Publicado: (2022)

LD-Spline: Mapping SNPs on genotyping platforms to genomic regions using patterns of linkage disequilibrium
por: Bush, William S, et al.
Publicado: (2009)

A Comprehensive In Silico Analysis of the Functional and Structural Impact of Nonsynonymous SNPs in the ABCA1 Transporter Gene
por: Marín-Martín, Francisco R., et al.
Publicado: (2014)

The investigation of nonsynonymous SNPs of human SLC6A4 gene associated with depression: An in silico approach
por: Hasan, Md. Amit, et al.
Publicado: (2021)

Exploring the Structural and Functional Effects of Nonsynonymous SNPs in the Human Serotonin Transporter Gene Through In Silico Approaches
por: Mia, Md Arzo, et al.
Publicado: (2022)

Are Nonsynonymous Transversions Generally More Deleterious than Nonsynonymous Transitions?
por: Zou, Zhengting, et al.
Publicado: (2020)

Mixture SNPs effect on phenotype in genome-wide association studies
por: Wang, Ling, et al.
Publicado: (2015)

Dissimilarity based Partial Least Squares (DPLS) for genomic prediction from SNPs
por: Singh, Priyanka, et al.
Publicado: (2016)

A Simulation Analysis and Screening of Deleterious Nonsynonymous Single Nucleotide Polymorphisms (nsSNPs) in Sheep LEP Gene
por: Girmay, Shishay, et al.
Publicado: (2022)

In Silico Evaluation of Nonsynonymous SNPs in Human ADAM33: The Most Common Form of Genetic Association to Asthma Susceptibility
por: Mohkam, Milad, et al.
Publicado: (2022)

USRCAT: real-time ultrafast shape recognition with pharmacophoric constraints
por: Schreyer, Adrian M, et al.
Publicado: (2012)

Performance of random forest when SNPs are in linkage disequilibrium
por: Meng, Yan A, et al.
Publicado: (2009)

MethylToSNP: identifying SNPs in Illumina DNA methylation array data
por: LaBarre, Brenna A., et al.
Publicado: (2019)

Inference of kinship using spatial distributions of SNPs for genome-wide association studies
por: Lee, Hyokyeong, et al.
Publicado: (2016)

Improved inference of site-specific positive selection under a generalized parametric codon model when there are multinucleotide mutations and multiple nonsynonymous rates
por: Dunn, Katherine A., et al.
Publicado: (2019)

Simultaneous Analysis of Common and Rare Variants in Complex Traits: Application to SNPs (SCARVAsnp)
por: Chen, Guanjie, et al.
Publicado: (2012)

On the evolutionary conservation of hydrogen bonds made by buried polar amino acids: the hidden joists, braces and trusses of protein architecture
por: Worth, Catherine L, et al.
Publicado: (2010)

Systematic exploration of predicted destabilizing nonsynonymous single nucleotide polymorphisms (nsSNPs) of human aldehyde oxidase: A Bio‐informatics study
por: Coelho, Catarina, et al.
Publicado: (2019)

Validation of a new hand-held electronic data capture method for continuous monitoring of subjective appetite sensations
por: Gibbons, Catherine, et al.
Publicado: (2011)

Prediction and Structural Comparison of Deleterious Coding Nonsynonymous Single Nucleotide Polymorphisms (nsSNPs) in Human LEP Gene Associated with Obesity
por: Bouafi, Hind, et al.
Publicado: (2019)

In silico screening and analysis of nonsynonymous SNPs in human CYP1A2 to assess possible associations with pathogenicity and cancer susceptibility
por: Navapour, Leila, et al.
Publicado: (2021)

Prediction and expression analysis of deleterious nonsynonymous SNPs of Arabidopsis ACD11 gene by combining computational algorithms and molecular docking approach
por: Rifat, Mahmudul Hasan, et al.
Publicado: (2022)

Investigating the utility of combining Φ29 whole genome amplification and highly multiplexed single nucleotide polymorphism BeadArray™ genotyping
por: Pask, Rebecca, et al.
Publicado: (2004)

Single-track sequencing for genotyping of multiple SNPs in the N-acetyltransferase 1 (NAT1) gene
por: Soucek, Pavel, et al.
Publicado: (2004)

In silico profiling of nonsynonymous SNPs of fat mass and obesity-associated gene: possible impacts on the treatment of non-alcoholic fatty liver disease
por: Patnaik, Damini, et al.
Publicado: (2023)

Genic constraint against nonsynonymous variation across the mouse genome
por: Powell, George, et al.
Publicado: (2023)

A model-based approach to selection of tag SNPs
por: Nicolas, Pierre, et al.
Publicado: (2006)

Quick, “Imputation-free” meta-analysis with proxy-SNPs
por: Meesters, Christian, et al.
Publicado: (2012)

Jackknife-based gene-gene interactiontests for untyped SNPs
por: Song, Minsun
Publicado: (2015)

SDM—a server for predicting effects of mutations on protein stability and malfunction
por: Worth, Catherine L., et al.
Publicado: (2011)

Methodology for Constructing Problem Definitions in Bioinformatics
por: Hauth, Amy M., et al.
Publicado: (2008)

Cannot write session to /tmp/vufind_sessions/sess_16c73j2qchs3ncal40bst1i9hn