Phylodynamics of HIV-1 in Lymphoid and Non-Lymphoid Tissues Reveals a Central Role for the Thymus in Emergence of CXCR4-Using Quasispecies

BACKGROUND: During HIV-1 infection coreceptor switch from CCR5- (R5)- to CXCR4 (X4)-using viruses is associated with disease progression. X4 strains of HIV-1 are highly cytopathic to immature thymocytes. Virtually no studies have evaluated the HIV-1 quasispecies present in vivo within thymic and lym...

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Detalles Bibliográficos
Autores principales: Salemi, Marco, Burkhardt, Brant R., Gray, Rebecca R., Ghaffari, Guity, Sleasman, John W., Goodenow, Maureen M.
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2007
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1978532/
https://www.ncbi.nlm.nih.gov/pubmed/17895991
http://dx.doi.org/10.1371/journal.pone.0000950

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