Cargando…
Basal shuttle of NF-κB/IκBα in resting T lymphocytes regulates HIV-1 LTR dependent expression
BACKGROUND: In HIV-infected T lymphocytes, NF-κB/Rel transcription factors are major elements involved in the activation of LTR-dependent transcription from latency. Most NF-κB heterodimer p65/p50 is sequestered as an inactive form in the cytoplasm of resting T lymphocytes via its interaction with I...
Autores principales: | Coiras, Mayte, López-Huertas, María Rosa, Rullas, Joaquín, Mittelbrunn, Maria, Alcamí, José |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2007
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1988826/ https://www.ncbi.nlm.nih.gov/pubmed/17686171 http://dx.doi.org/10.1186/1742-4690-4-56 |
Ejemplares similares
-
Caspase-3-mediated cleavage of p65/RelA results in a carboxy-terminal fragment that inhibits IκBα and enhances HIV-1 replication in human T lymphocytes
por: Coiras, Mayte, et al.
Publicado: (2008) -
PKCθ and HIV-1 Transcriptional Regulator Tat Co-exist at the LTR Promoter in CD4(+) T Cells
por: López-Huertas, María Rosa, et al.
Publicado: (2016) -
Molecular mechanisms involved in HIV latency and implications for HIV treatment and eradication
por: Alcami, Jose, et al.
Publicado: (2010) -
Nuclear Transit and HIV LTR Binding of NF-κB Subunits Held by IκB Proteins: Implications for HIV-1 Activation
por: Khan, Sohrab Z., et al.
Publicado: (2019) -
High-Throughput Analysis of NF-κB Dynamics in Single Cells Reveals Basal Nuclear Localization of NF-κB and Spontaneous Activation of Oscillations
por: Zambrano, Samuel, et al.
Publicado: (2014)