Comparing the DNA Hypermethylome with Gene Mutations in Human Colorectal Cancer

We have developed a transcriptome-wide approach to identify genes affected by promoter CpG island DNA hypermethylation and transcriptional silencing in colorectal cancer. By screening cell lines and validating tumor-specific hypermethylation in a panel of primary human colorectal cancer samples, we...

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Detalles Bibliográficos
Autores principales: Schuebel, Kornel E, Chen, Wei, Cope, Leslie, Glöckner, Sabine C, Suzuki, Hiromu, Yi, Joo-Mi, Chan, Timothy A, Neste, Leander Van, Criekinge, Wim Van, van den Bosch, Sandra, van Engeland, Manon, Ting, Angela H, Jair, Kamwing, Yu, Wayne, Toyota, Minoru, Imai, Kohzoh, Ahuja, Nita, Herman, James G, Baylin, Stephen B
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2007
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1988850/
https://www.ncbi.nlm.nih.gov/pubmed/17892325
http://dx.doi.org/10.1371/journal.pgen.0030157

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