Cargando…

Nonsteroidal Antiinflammatory Drugs are Associated with Increased Aortic Stiffness

OBJECTIVES: Nonsteroidal antiinflammatory drugs (NSAIDS) have been shown to retard aneurysm growth in animal models. In vitro studies have shown an inhibitory effect of NSAIDS on matrix metalloproteinase-9, interleukin-1β, and IL-6 mediated arterial wall elastolysis. The aim of this study was to inv...

Descripción completa

Detalles Bibliográficos
Autores principales: Claridge, Martin, Hobbs, Simon, Quick, Clive, Day, Nick, Bradbury, Andrew, Wilmink, Teun
Formato: Texto
Lenguaje:English
Publicado: Dove Medical Press 2005
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1993941/
https://www.ncbi.nlm.nih.gov/pubmed/17315401
_version_ 1782135451387166720
author Claridge, Martin
Hobbs, Simon
Quick, Clive
Day, Nick
Bradbury, Andrew
Wilmink, Teun
author_facet Claridge, Martin
Hobbs, Simon
Quick, Clive
Day, Nick
Bradbury, Andrew
Wilmink, Teun
author_sort Claridge, Martin
collection PubMed
description OBJECTIVES: Nonsteroidal antiinflammatory drugs (NSAIDS) have been shown to retard aneurysm growth in animal models. In vitro studies have shown an inhibitory effect of NSAIDS on matrix metalloproteinase-9, interleukin-1β, and IL-6 mediated arterial wall elastolysis. The aim of this study was to investigate the effects of NSAIDs on arterial stiffness, a surrogate marker of elastolysis. METHODS: 447 subjects enrolled in a community-based abdominal aortic aneurysm (AAA) screening program were assessed for age, blood pressure, smoking status, and drug history. Aortic diameter and stiffness were measured by M-Mode ultrasound. The concentration of the amino-terminal propeptide of type III procollagen was used as a proxy measurement of type III collagen turnover. RESULTS: NSAID ingestion was significantly (p = 0.006) associated with increased aortic wall stiffness after adjusting for age, aortic diameter, blood pressure, and smoking status. No such effect was seen for β-blockers, calcium channel antagonists, nitrates, angiotensin-converting enzyme inhibitors, diuretics, or antiplatelet agents. DISCUSSION: These novel data show that NSAIDS are associated with increased aortic stiffness, possibly through the effects of cytokine mediated elastolysis. This in turn may prevent aortic expansion and the development of AAA.
format Text
id pubmed-1993941
institution National Center for Biotechnology Information
language English
publishDate 2005
publisher Dove Medical Press
record_format MEDLINE/PubMed
spelling pubmed-19939412008-03-06 Nonsteroidal Antiinflammatory Drugs are Associated with Increased Aortic Stiffness Claridge, Martin Hobbs, Simon Quick, Clive Day, Nick Bradbury, Andrew Wilmink, Teun Vasc Health Risk Manag Original Research OBJECTIVES: Nonsteroidal antiinflammatory drugs (NSAIDS) have been shown to retard aneurysm growth in animal models. In vitro studies have shown an inhibitory effect of NSAIDS on matrix metalloproteinase-9, interleukin-1β, and IL-6 mediated arterial wall elastolysis. The aim of this study was to investigate the effects of NSAIDs on arterial stiffness, a surrogate marker of elastolysis. METHODS: 447 subjects enrolled in a community-based abdominal aortic aneurysm (AAA) screening program were assessed for age, blood pressure, smoking status, and drug history. Aortic diameter and stiffness were measured by M-Mode ultrasound. The concentration of the amino-terminal propeptide of type III procollagen was used as a proxy measurement of type III collagen turnover. RESULTS: NSAID ingestion was significantly (p = 0.006) associated with increased aortic wall stiffness after adjusting for age, aortic diameter, blood pressure, and smoking status. No such effect was seen for β-blockers, calcium channel antagonists, nitrates, angiotensin-converting enzyme inhibitors, diuretics, or antiplatelet agents. DISCUSSION: These novel data show that NSAIDS are associated with increased aortic stiffness, possibly through the effects of cytokine mediated elastolysis. This in turn may prevent aortic expansion and the development of AAA. Dove Medical Press 2005-06 2005-06 /pmc/articles/PMC1993941/ /pubmed/17315401 Text en © 2005 Dove Medical Press Limited. All rights reserved
spellingShingle Original Research
Claridge, Martin
Hobbs, Simon
Quick, Clive
Day, Nick
Bradbury, Andrew
Wilmink, Teun
Nonsteroidal Antiinflammatory Drugs are Associated with Increased Aortic Stiffness
title Nonsteroidal Antiinflammatory Drugs are Associated with Increased Aortic Stiffness
title_full Nonsteroidal Antiinflammatory Drugs are Associated with Increased Aortic Stiffness
title_fullStr Nonsteroidal Antiinflammatory Drugs are Associated with Increased Aortic Stiffness
title_full_unstemmed Nonsteroidal Antiinflammatory Drugs are Associated with Increased Aortic Stiffness
title_short Nonsteroidal Antiinflammatory Drugs are Associated with Increased Aortic Stiffness
title_sort nonsteroidal antiinflammatory drugs are associated with increased aortic stiffness
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1993941/
https://www.ncbi.nlm.nih.gov/pubmed/17315401
work_keys_str_mv AT claridgemartin nonsteroidalantiinflammatorydrugsareassociatedwithincreasedaorticstiffness
AT hobbssimon nonsteroidalantiinflammatorydrugsareassociatedwithincreasedaorticstiffness
AT quickclive nonsteroidalantiinflammatorydrugsareassociatedwithincreasedaorticstiffness
AT daynick nonsteroidalantiinflammatorydrugsareassociatedwithincreasedaorticstiffness
AT bradburyandrew nonsteroidalantiinflammatorydrugsareassociatedwithincreasedaorticstiffness
AT wilminkteun nonsteroidalantiinflammatorydrugsareassociatedwithincreasedaorticstiffness