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Pathophysiology of Tumor Neovascularization
Neovascularization is essential to the process of development and differentiation of tissues in the vertebrate embryo, and is also involved in a wide variety of physiological and pathological conditions in adults, including wound repair, metabolic diseases, inflammation, cardiovascular disorders, an...
Autores principales: | , , , , |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2005
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1993966/ https://www.ncbi.nlm.nih.gov/pubmed/17315600 |
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author | Furuya, Mitsuko Nishiyama, Mariko Kasuya, Yoshitoshi Kimura, Sadao Ishikura, Hiroshi |
author_facet | Furuya, Mitsuko Nishiyama, Mariko Kasuya, Yoshitoshi Kimura, Sadao Ishikura, Hiroshi |
author_sort | Furuya, Mitsuko |
collection | PubMed |
description | Neovascularization is essential to the process of development and differentiation of tissues in the vertebrate embryo, and is also involved in a wide variety of physiological and pathological conditions in adults, including wound repair, metabolic diseases, inflammation, cardiovascular disorders, and tumor progression. Thanks to cumulative studies on vasculature, new therapeutic approaches have been opened for us to some life-threatening diseases by controlling angiogenesis in the affected organs. In cancer therapy, for example, modulation of factors responsible for tumor angiogenesis may be beneficial in inhibiting of tumor progression. Several antiangiogenic approaches are currently under preclinical trial. However, the mechanisms of neovascularization in tumors are complicated and each tumor shows unique features in its vasculature, depending on tissue specificity, angiogenic micromilieu, grades and stages, host immunity, and so on. For better understanding and effective therapeutic approaches, it is important to clarify both the general mechanism of angiogenic events and the disease-specific mechanism of neovascularization. This review discusses the general features of angiogenesis under physiological and pathological conditions, mainly in tumor progression. In addition, recent topics such as contribution of the endothelial progenitor cells, tumor vasculogenic mimicry, markers for tumor-derived endothelial cells and pericytes, and angiogenic/angiostatic chemokines are summarized. |
format | Text |
id | pubmed-1993966 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2005 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-19939662008-03-06 Pathophysiology of Tumor Neovascularization Furuya, Mitsuko Nishiyama, Mariko Kasuya, Yoshitoshi Kimura, Sadao Ishikura, Hiroshi Vasc Health Risk Manag Review Neovascularization is essential to the process of development and differentiation of tissues in the vertebrate embryo, and is also involved in a wide variety of physiological and pathological conditions in adults, including wound repair, metabolic diseases, inflammation, cardiovascular disorders, and tumor progression. Thanks to cumulative studies on vasculature, new therapeutic approaches have been opened for us to some life-threatening diseases by controlling angiogenesis in the affected organs. In cancer therapy, for example, modulation of factors responsible for tumor angiogenesis may be beneficial in inhibiting of tumor progression. Several antiangiogenic approaches are currently under preclinical trial. However, the mechanisms of neovascularization in tumors are complicated and each tumor shows unique features in its vasculature, depending on tissue specificity, angiogenic micromilieu, grades and stages, host immunity, and so on. For better understanding and effective therapeutic approaches, it is important to clarify both the general mechanism of angiogenic events and the disease-specific mechanism of neovascularization. This review discusses the general features of angiogenesis under physiological and pathological conditions, mainly in tumor progression. In addition, recent topics such as contribution of the endothelial progenitor cells, tumor vasculogenic mimicry, markers for tumor-derived endothelial cells and pericytes, and angiogenic/angiostatic chemokines are summarized. Dove Medical Press 2005-12 2005-12 /pmc/articles/PMC1993966/ /pubmed/17315600 Text en © 2005 Dove Medical Press Limited. All rights reserved |
spellingShingle | Review Furuya, Mitsuko Nishiyama, Mariko Kasuya, Yoshitoshi Kimura, Sadao Ishikura, Hiroshi Pathophysiology of Tumor Neovascularization |
title | Pathophysiology of Tumor Neovascularization |
title_full | Pathophysiology of Tumor Neovascularization |
title_fullStr | Pathophysiology of Tumor Neovascularization |
title_full_unstemmed | Pathophysiology of Tumor Neovascularization |
title_short | Pathophysiology of Tumor Neovascularization |
title_sort | pathophysiology of tumor neovascularization |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1993966/ https://www.ncbi.nlm.nih.gov/pubmed/17315600 |
work_keys_str_mv | AT furuyamitsuko pathophysiologyoftumorneovascularization AT nishiyamamariko pathophysiologyoftumorneovascularization AT kasuyayoshitoshi pathophysiologyoftumorneovascularization AT kimurasadao pathophysiologyoftumorneovascularization AT ishikurahiroshi pathophysiologyoftumorneovascularization |