Cargando…

Ximelagatran: Direct Thrombin Inhibitor

Warfarin sodium is an effective oral anticoagulant drug. However, warfarin has a narrow therapeutic window with significant risks of hemorrhage at therapeutic concentrations. Dosing is difficult and requires frequent monitoring. New oral anticoagulant agents are required to improve current anticoagu...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ho, Shir-Jing, Brighton, Tim A
Formato:	Texto
Lenguaje:	English
Publicado:	Dove Medical Press 2006
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1993972/ https://www.ncbi.nlm.nih.gov/pubmed/17319469

Ejemplares similares

Anticoagulation for non-valvular atrial aibrillation – towards a new beginning with ximelagatran
por: Boos, Christopher J, et al.
Publicado: (2004)

Expression and Function of mARC: Roles in Lipogenesis and Metabolic Activation of Ximelagatran
por: Neve, Etienne P. A., et al.
Publicado: (2015)

In Silico and In Vitro Analysis of Interaction between Ximelagatran and Human Leukocyte Antigen (HLA)-DRB1*07:01
por: Hirasawa, Makoto, et al.
Publicado: (2017)

Reversible covalent direct thrombin inhibitors
por: Sivaraja, Mohanram, et al.
Publicado: (2018)

Anticoagulation with direct thrombin inhibitors during extracorporeal membrane oxygenation
por: Burstein, Barry, et al.
Publicado: (2019)

New Approaches to the Role of Thrombin in Acute Coronary Syndromes: Quo Vadis Bivalirudin, a Direct Thrombin Inhibitor?
por: Esteve-Pastor, María Asunción, et al.
Publicado: (2016)

HLA-DR7 and HLA-DQ2: Transgenic mouse strains tested as a model system for ximelagatran hepatotoxicity
por: Lundgren, Hanna, et al.
Publicado: (2017)

Aprotinin Inhibits Thrombin Generation by Inhibition of the Intrinsic Pathway, but is not a Direct Thrombin Inhibitor
por: Lisman, Ton, et al.
Publicado: (2021)

Thrombin Inhibitors from Different Animals
por: Tanaka-Azevedo, A. M., et al.
Publicado: (2010)

The direct thrombin inhibitor argatroban: a review of its use in patients with and without HIT
por: Koster, Andreas, et al.
Publicado: (2007)

Boehringer launches first direct thrombin inhibitor: dabigatran (Pradaxa®)
Publicado: (2010)

Efficacy and safety of next-generation tick transcriptome-derived direct thrombin inhibitors
por: Koh, Cho Yeow, et al.
Publicado: (2021)

Thrombin Activatable Fibrinolysis Inhibitor (TAFI): An Updated Narrative Review
por: Sillen, Machteld, et al.
Publicado: (2021)

Alzheimer’s Disease—Rationales for Potential Treatment with the Thrombin Inhibitor Dabigatran
por: Grossmann, Klaus
Publicado: (2021)

Direct thrombin inhibitors, but not the direct factor Xa inhibitor rivaroxaban, increase tissue factor-induced hypercoagulability in vitro and in vivo
por: Perzborn, E, et al.
Publicado: (2014)

Impaired in vitro thrombin generation in β2-glycoprotein I null mice
por: Sheng, Y, et al.
Publicado: (2001)

Oral direct thrombin inhibition: a double-edged sword?
por: Fragasso, Gabriele, et al.
Publicado: (2015)

Effect of a Direct Thrombin Inhibitor Compared with Dalteparin and Unfractionated Heparin on Human Osteoblasts
por: Winkler, Tobias, et al.
Publicado: (2011)

Direct Thrombin Inhibitors Prevent Left Atrial Remodeling Associated With Heart Failure in Rats
por: Jumeau, Céline, et al.
Publicado: (2016)

The Changing Landscape of Anticoagulation in Pediatric Extracorporeal Membrane Oxygenation: Use of the Direct Thrombin Inhibitors
por: Neunert, Cindy, et al.
Publicado: (2022)

Development of Orally Active Thrombin Inhibitors for the Treatment of Thrombotic Disorder Diseases
por: He, Li-Wei, et al.
Publicado: (2015)

New oral antithrombotics: focus on dabigatran, an oral, reversible direct thrombin inhibitor for the prevention and treatment of venous and arterial thromboembolic disorders
por: Dahl, Ola E
Publicado: (2012)

Purification and characterization of thrombin from camel plasma: interaction with camel tick salivary gland thrombin inhibitor
por: Ibrahim, Mahmoud A., et al.
Publicado: (2023)

Rational Design and Characterization of D-Phe-Pro-D-Arg-Derived Direct Thrombin Inhibitors
por: Figueiredo, Ana C., et al.
Publicado: (2012)

Crystal Structure of Thrombin in Complex with S-Variegin: Insights of a Novel Mechanism of Inhibition and Design of Tunable Thrombin Inhibitors
por: Koh, Cho Yeow, et al.
Publicado: (2011)

Dabigatran, a direct thrombin inhibitor, can be a life-saving treatment in heparin-induced thrombocytopenia
por: Mirdamadi, Ahmad
Publicado: (2013)

Comparison of antithrombin‐dependent and direct inhibitors of factor Xa or thrombin on the kinetics and qualitative characteristics of blood clots
por: Salta, Stella, et al.
Publicado: (2018)

Development and validation of an analytical method for the determination of direct oral anticoagulants (DOAC) and the direct thrombin-inhibitor argatroban by HPLC–MS/MS
por: Brückner, Lea, et al.
Publicado: (2021)

Influence of Aromatic and Aliphatic Moieties on Thrombin Inhibitors Potency
por: Poyarkov, Alexey, et al.
Publicado: (2008)

New Synthetic Thrombin Inhibitors: Molecular Design and Experimental Verification
por: Sinauridze, Elena I., et al.
Publicado: (2011)

Screening of the Promising Direct Thrombin Inhibitors from Haematophagous Organisms. Part I: Recombinant Analogues and Their Antithrombotic Activity In Vitro
por: Kostromina, Maria A., et al.
Publicado: (2021)

Platelet thrombin receptor antagonism and atherothrombosis
por: Angiolillo, Dominick J., et al.
Publicado: (2010)

Thrombin Receptor Antagonism in Antiplatelet Therapy
por: Olivier, C., et al.
Publicado: (2013)

The Importance of Thrombin in Cerebral Injury and Disease
por: Krenzlin, Harald, et al.
Publicado: (2016)

Thrombin Generation and Cancer: Contributors and Consequences
por: Reddel, Caroline J., et al.
Publicado: (2019)

Intervention in COVID-19 linked hypercoaguable states characterized by circuit thrombosis utilizing a direct thrombin inhibitor
por: Seshadri, Madhav, et al.
Publicado: (2020)

Anticoagulation Strategies in Critically Ill Patients With SARS-CoV-2 Infection: The Role of Direct Thrombin Inhibitors
por: Pieri, Marina, et al.
Publicado: (2022)

Reversing direct factor Xa or thrombin inhibitors: Factor V addition to prothrombin complex concentrate is beneficial in vitro
por: Brinkman, Herm Jan M., et al.
Publicado: (2022)

PURIFICATION OF THROMBIN
por: Milstone, H.
Publicado: (1942)

Post-operative thromboprophylaxis: new oral thrombin and factor X inhibitors and their place in clinical practice
por: Filipovic, Miodrag, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_h01vq12hidprjsrdr6l715np80