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MSN2 and MSN4 Link Calorie Restriction and TOR to Sirtuin-Mediated Lifespan Extension in Saccharomyces cerevisiae

Calorie restriction (CR) robustly extends the lifespan of numerous species. In the yeast Saccharomyces cerevisiae, CR has been proposed to extend lifespan by boosting the activity of sirtuin deacetylases, thereby suppressing the formation of toxic repetitive ribosomal DNA (rDNA) circles. An alternat...

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Detalles Bibliográficos
Autores principales:	Medvedik, Oliver, Lamming, Dudley W, Kim, Keyman D, Sinclair, David A
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2007
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1994990/ https://www.ncbi.nlm.nih.gov/pubmed/17914901 http://dx.doi.org/10.1371/journal.pbio.0050261

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