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Leptin promotes rapid dynamic changes in hippocampal dendritic morphology

Recent studies have implicated the hormone leptin in synaptic plasticity associated with neuronal development and learning and memory. Indeed, leptin facilitates hippocampal long-term potentiation and leptin-insensitive rodents display impaired hippocampal synaptic plasticity suggesting a role for e...

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Detalles Bibliográficos
Autores principales: O’Malley, Dervla, MacDonald, Neil, Mizielinska, Sarah, Connolly, Christopher N., Irving, Andrew J., Harvey, Jenni
Formato: Texto
Lenguaje:English
Publicado: Academic Press 2007
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1995039/
https://www.ncbi.nlm.nih.gov/pubmed/17618127
http://dx.doi.org/10.1016/j.mcn.2007.05.001
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author O’Malley, Dervla
MacDonald, Neil
Mizielinska, Sarah
Connolly, Christopher N.
Irving, Andrew J.
Harvey, Jenni
author_facet O’Malley, Dervla
MacDonald, Neil
Mizielinska, Sarah
Connolly, Christopher N.
Irving, Andrew J.
Harvey, Jenni
author_sort O’Malley, Dervla
collection PubMed
description Recent studies have implicated the hormone leptin in synaptic plasticity associated with neuronal development and learning and memory. Indeed, leptin facilitates hippocampal long-term potentiation and leptin-insensitive rodents display impaired hippocampal synaptic plasticity suggesting a role for endogenous leptin. Structural changes are also thought to underlie activity-dependent synaptic plasticity and this may be regulated by specific growth factors. As leptin is reported to have neurotrophic actions, we have examined the effects of leptin on the morphology and filopodial outgrowth in hippocampal neurons. Here, we demonstrate that leptin rapidly enhances the motility and density of dendritic filopodia and subsequently increases the density of hippocampal synapses. This process is dependent on the synaptic activation of NR2A-containing NMDA receptors and is mediated by the MAPK (ERK) signaling pathway. As dendritic morphogenesis is associated with activity-dependent changes in synaptic strength, the rapid structural remodeling of dendrites by leptin has important implications for its role in regulating hippocampal synaptic plasticity and neuronal development.
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spelling pubmed-19950392008-08-29 Leptin promotes rapid dynamic changes in hippocampal dendritic morphology O’Malley, Dervla MacDonald, Neil Mizielinska, Sarah Connolly, Christopher N. Irving, Andrew J. Harvey, Jenni Mol Cell Neurosci Article Recent studies have implicated the hormone leptin in synaptic plasticity associated with neuronal development and learning and memory. Indeed, leptin facilitates hippocampal long-term potentiation and leptin-insensitive rodents display impaired hippocampal synaptic plasticity suggesting a role for endogenous leptin. Structural changes are also thought to underlie activity-dependent synaptic plasticity and this may be regulated by specific growth factors. As leptin is reported to have neurotrophic actions, we have examined the effects of leptin on the morphology and filopodial outgrowth in hippocampal neurons. Here, we demonstrate that leptin rapidly enhances the motility and density of dendritic filopodia and subsequently increases the density of hippocampal synapses. This process is dependent on the synaptic activation of NR2A-containing NMDA receptors and is mediated by the MAPK (ERK) signaling pathway. As dendritic morphogenesis is associated with activity-dependent changes in synaptic strength, the rapid structural remodeling of dendrites by leptin has important implications for its role in regulating hippocampal synaptic plasticity and neuronal development. Academic Press 2007-08 /pmc/articles/PMC1995039/ /pubmed/17618127 http://dx.doi.org/10.1016/j.mcn.2007.05.001 Text en © 2007 Elsevier Inc. https://creativecommons.org/licenses/by/3.0/ Open Access under CC BY 3.0 (https://creativecommons.org/licenses/by/3.0/) license
spellingShingle Article
O’Malley, Dervla
MacDonald, Neil
Mizielinska, Sarah
Connolly, Christopher N.
Irving, Andrew J.
Harvey, Jenni
Leptin promotes rapid dynamic changes in hippocampal dendritic morphology
title Leptin promotes rapid dynamic changes in hippocampal dendritic morphology
title_full Leptin promotes rapid dynamic changes in hippocampal dendritic morphology
title_fullStr Leptin promotes rapid dynamic changes in hippocampal dendritic morphology
title_full_unstemmed Leptin promotes rapid dynamic changes in hippocampal dendritic morphology
title_short Leptin promotes rapid dynamic changes in hippocampal dendritic morphology
title_sort leptin promotes rapid dynamic changes in hippocampal dendritic morphology
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1995039/
https://www.ncbi.nlm.nih.gov/pubmed/17618127
http://dx.doi.org/10.1016/j.mcn.2007.05.001
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