Cargando…
Variable Expression of Cre Recombinase Transgenes Precludes Reliable Prediction of Tissue-Specific Gene Disruption by Tail-Biopsy Genotyping
The Cre/loxP-system has become the system of choice for the generation of conditional so-called knockout mouse strains, i.e. the tissue-specific disruption of expression of a certain target gene. We here report the loss of expression of Cre recombinase in a transgenic mouse strain with increasing nu...
Autores principales: | Schulz, Tim J., Glaubitz, Markus, Kuhlow, Doreen, Thierbach, René, Birringer, Marc, Steinberg, Pablo, Pfeiffer, Andreas F. H., Ristow, Michael |
---|---|
Formato: | Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2007
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1995755/ https://www.ncbi.nlm.nih.gov/pubmed/17925861 http://dx.doi.org/10.1371/journal.pone.0001013 |
Ejemplares similares
-
Transgenic Mice for a Tamoxifen-Induced, Conditional Expression of the Cre Recombinase in Osteoclasts
por: Sanchez-Fernandez, Maria Arantzazu, et al.
Publicado: (2012) -
Generation and Characterization of a Transgenic Mouse That Specifically Expresses the Cre Recombinase in Spermatids
por: Gobé, Clara, et al.
Publicado: (2023) -
The Friedreich's ataxia protein frataxin modulates DNA base excision repair in prokaryotes and mammals
por: Thierbach, René, et al.
Publicado: (2010) -
Targeted Expression of Cre Recombinase Provokes Placental-Specific DNA Recombination in Transgenic Mice
por: Zhou, Cissy Chenyi, et al.
Publicado: (2012) -
Generation of transgenic mouse line with prostate-specific expression of codon-improved Cre recombinase
por: Kanayama, Mayuko, et al.
Publicado: (2018)