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Understanding hereditary diseases using the dog and human as companion model systems
Animal models are requisite for genetic dissection of, and improved treatment regimens for, human hereditary diseases. While several animals have been used in academic and industrial research, the primary model for dissection of hereditary diseases has been the many strains of the laboratory mouse....
Autores principales: | , , |
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Formato: | Texto |
Lenguaje: | English |
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Springer New York
2007
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1998873/ https://www.ncbi.nlm.nih.gov/pubmed/17653794 http://dx.doi.org/10.1007/s00335-007-9037-1 |
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author | Tsai, Kate L. Clark, Leigh Anne Murphy, Keith E. |
author_facet | Tsai, Kate L. Clark, Leigh Anne Murphy, Keith E. |
author_sort | Tsai, Kate L. |
collection | PubMed |
description | Animal models are requisite for genetic dissection of, and improved treatment regimens for, human hereditary diseases. While several animals have been used in academic and industrial research, the primary model for dissection of hereditary diseases has been the many strains of the laboratory mouse. However, given its greater (than the mouse) genetic similarity to the human, high number of naturally occurring hereditary diseases, unique population structure, and the availability of the complete genome sequence, the purebred dog has emerged as a powerful model for study of diseases. The major advantage the dog provides is that it is afflicted with approximately 450 hereditary diseases, about half of which have remarkable clinical similarities to corresponding diseases of the human. In addition, humankind has a strong desire to cure diseases of the dog so these two facts make the dog an ideal clinical and genetic model. This review highlights several of these shared hereditary diseases. Specifically, the canine models discussed herein have played important roles in identification of causative genes and/or have been utilized in novel therapeutic approaches of interest to the dog and human. |
format | Text |
id | pubmed-1998873 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2007 |
publisher | Springer New York |
record_format | MEDLINE/PubMed |
spelling | pubmed-19988732007-10-02 Understanding hereditary diseases using the dog and human as companion model systems Tsai, Kate L. Clark, Leigh Anne Murphy, Keith E. Mamm Genome Article Animal models are requisite for genetic dissection of, and improved treatment regimens for, human hereditary diseases. While several animals have been used in academic and industrial research, the primary model for dissection of hereditary diseases has been the many strains of the laboratory mouse. However, given its greater (than the mouse) genetic similarity to the human, high number of naturally occurring hereditary diseases, unique population structure, and the availability of the complete genome sequence, the purebred dog has emerged as a powerful model for study of diseases. The major advantage the dog provides is that it is afflicted with approximately 450 hereditary diseases, about half of which have remarkable clinical similarities to corresponding diseases of the human. In addition, humankind has a strong desire to cure diseases of the dog so these two facts make the dog an ideal clinical and genetic model. This review highlights several of these shared hereditary diseases. Specifically, the canine models discussed herein have played important roles in identification of causative genes and/or have been utilized in novel therapeutic approaches of interest to the dog and human. Springer New York 2007-07-01 2007 /pmc/articles/PMC1998873/ /pubmed/17653794 http://dx.doi.org/10.1007/s00335-007-9037-1 Text en © Springer Science+Business Media, LLC 2007 https://creativecommons.org/licenses/by-nc/2.0/ Open Access This is an open access article distributed under the terms of the Creative Commons Attribution Noncommercial License ( https://creativecommons.org/licenses/by-nc/2.0 (https://creativecommons.org/licenses/by-nc/2.0/) ), which permits any noncommercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited. |
spellingShingle | Article Tsai, Kate L. Clark, Leigh Anne Murphy, Keith E. Understanding hereditary diseases using the dog and human as companion model systems |
title | Understanding hereditary diseases using the dog and human as companion model systems |
title_full | Understanding hereditary diseases using the dog and human as companion model systems |
title_fullStr | Understanding hereditary diseases using the dog and human as companion model systems |
title_full_unstemmed | Understanding hereditary diseases using the dog and human as companion model systems |
title_short | Understanding hereditary diseases using the dog and human as companion model systems |
title_sort | understanding hereditary diseases using the dog and human as companion model systems |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1998873/ https://www.ncbi.nlm.nih.gov/pubmed/17653794 http://dx.doi.org/10.1007/s00335-007-9037-1 |
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