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New pleiotropic effects of eliminating a rare tRNA from Streptomyces coelicolor, revealed by combined proteomic and transcriptomic analysis of liquid cultures
BACKGROUND: In Streptomyces coelicolor, bldA encodes the only tRNA for a rare leucine codon, UUA. This tRNA is unnecessary for growth, but is required for some aspects of secondary metabolism and morphological development. We describe a transcriptomic and proteomic analysis of the effects of deletin...
Autores principales: | Hesketh, Andy, Bucca, Giselda, Laing, Emma, Flett, Fiona, Hotchkiss, Graham, Smith, Colin P, Chater, Keith F |
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Formato: | Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2007
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2000904/ https://www.ncbi.nlm.nih.gov/pubmed/17678549 http://dx.doi.org/10.1186/1471-2164-8-261 |
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