A Single Mutation in the PB1-F2 of H5N1 (HK/97) and 1918 Influenza A Viruses Contributes to Increased Virulence

The proapoptotic PB1-F2 protein of influenza A viruses has been shown to contribute to pathogenesis in the mouse model. Expression of full-length PB1-F2 increases the pathogenesis of the influenza A virus, causing weight loss, slower viral clearance, and increased viral titers in the lungs. After co...

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Detalles Bibliográficos
Autores principales: Conenello, Gina M, Zamarin, Dmitriy, Perrone, Lucy A, Tumpey, Terrence, Palese, Peter
Formato: Texto
Lenguaje:English
Publicado: Public Library of Science 2007
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2000966/
https://www.ncbi.nlm.nih.gov/pubmed/17922571
http://dx.doi.org/10.1371/journal.ppat.0030141

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