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Complement C3d Conjugation to Anthrax Protective Antigen Promotes a Rapid, Sustained, and Protective Antibody Response

B. anthracis is the causative agent of anthrax. Pathogenesis is primarily mediated through the exotoxins lethal factor and edema factor, which bind protective antigen (PA) to gain entry into the host cell. The current anthrax vaccine (AVA, Biothrax™) consists of aluminum-adsorbed cell-free filtrates...

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Detalles Bibliográficos
Autores principales:	Kolla, Ravi V., Chintalapati, Suresh, Sabet, Mojgan, Santelli, Eugenio, Liddington, Robert C., David, Michael, Fierer, Joshua, Guiney, Donald, Rickert, Robert C.
Formato:	Texto
Lenguaje:	English
Publicado:	Public Library of Science 2007
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2001179/ https://www.ncbi.nlm.nih.gov/pubmed/17940608 http://dx.doi.org/10.1371/journal.pone.0001044

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