The relation of ras family oncogene expression to conventional staging criteria and clinical outcome in colorectal carcinoma.

The elevated levels of ras-related cellular RNA in a series of colorectal carcinomata (n = 12) was correlated with conventional staging criteria (tumour morphology and Dukes' staging) and with clinical outcome with particular reference to the development of metastatic disease. No direct relatio...

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Autores principales: Kerr, I. B., Spandidos, D. A., Finlay, I. G., Lee, F. D., McArdle, C. S.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1986
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2001339/
https://www.ncbi.nlm.nih.gov/pubmed/3954944
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author Kerr, I. B.
Spandidos, D. A.
Finlay, I. G.
Lee, F. D.
McArdle, C. S.
author_facet Kerr, I. B.
Spandidos, D. A.
Finlay, I. G.
Lee, F. D.
McArdle, C. S.
author_sort Kerr, I. B.
collection PubMed
description The elevated levels of ras-related cellular RNA in a series of colorectal carcinomata (n = 12) was correlated with conventional staging criteria (tumour morphology and Dukes' staging) and with clinical outcome with particular reference to the development of metastatic disease. No direct relationship was evident between these parameters suggesting that although abnormal expression of ras oncogenes may be critical in the development of malignancy, variations in the level of their expression do not appear to be directly related to clinically evident phenotypic differences.
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spelling pubmed-20013392009-09-10 The relation of ras family oncogene expression to conventional staging criteria and clinical outcome in colorectal carcinoma. Kerr, I. B. Spandidos, D. A. Finlay, I. G. Lee, F. D. McArdle, C. S. Br J Cancer Research Article The elevated levels of ras-related cellular RNA in a series of colorectal carcinomata (n = 12) was correlated with conventional staging criteria (tumour morphology and Dukes' staging) and with clinical outcome with particular reference to the development of metastatic disease. No direct relationship was evident between these parameters suggesting that although abnormal expression of ras oncogenes may be critical in the development of malignancy, variations in the level of their expression do not appear to be directly related to clinically evident phenotypic differences. Nature Publishing Group 1986-02 /pmc/articles/PMC2001339/ /pubmed/3954944 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Kerr, I. B.
Spandidos, D. A.
Finlay, I. G.
Lee, F. D.
McArdle, C. S.
The relation of ras family oncogene expression to conventional staging criteria and clinical outcome in colorectal carcinoma.
title The relation of ras family oncogene expression to conventional staging criteria and clinical outcome in colorectal carcinoma.
title_full The relation of ras family oncogene expression to conventional staging criteria and clinical outcome in colorectal carcinoma.
title_fullStr The relation of ras family oncogene expression to conventional staging criteria and clinical outcome in colorectal carcinoma.
title_full_unstemmed The relation of ras family oncogene expression to conventional staging criteria and clinical outcome in colorectal carcinoma.
title_short The relation of ras family oncogene expression to conventional staging criteria and clinical outcome in colorectal carcinoma.
title_sort relation of ras family oncogene expression to conventional staging criteria and clinical outcome in colorectal carcinoma.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2001339/
https://www.ncbi.nlm.nih.gov/pubmed/3954944
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