Localisation of gastrointestinal cancer with a 131 I labelled monoclonal antibody to CEA.

The localisation of tumour deposits by a 131 I labelled monoclonal antibody to carcinoembryonic antigen (CEA) has been evaluated in 24 patients with primary gastric, oesophageal and colorectal cancer and in 26 patients with clinically suspected recurrent gastric and colorectal cancer. Seventeen of 2...

Descripción completa

Detalles Bibliográficos
Autores principales: Allum, W. H., MacDonald, F., Anderson, P., Fielding, J. W.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1986
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2001340/
https://www.ncbi.nlm.nih.gov/pubmed/3954942
_version_ 1782135585087946752
author Allum, W. H.
MacDonald, F.
Anderson, P.
Fielding, J. W.
author_facet Allum, W. H.
MacDonald, F.
Anderson, P.
Fielding, J. W.
author_sort Allum, W. H.
collection PubMed
description The localisation of tumour deposits by a 131 I labelled monoclonal antibody to carcinoembryonic antigen (CEA) has been evaluated in 24 patients with primary gastric, oesophageal and colorectal cancer and in 26 patients with clinically suspected recurrent gastric and colorectal cancer. Seventeen of 20 primary sites and 6/15 associated secondary sites were correctly identified by external scanning. Measurement of radiolabelled antibody in the resected specimens demonstrated a 2.6-3.3 fold increase in comparison with the surrounding normal tissue (P less than 0.01). The antibody scans were compared with computerised tomography (CT) in the detection of recurrent disease. The respective sensitivities and specificities for the two investigations were 61% and 33% for antibody scanning and 64% and 100% for CT. Assessment of the distribution of labelled antibody demonstrated rapid clearance with less than 2% detectable in serum samples at 24 h. The implications of these findings together with the mechanisms of excretion are discussed. IMAGES:
format Text
id pubmed-2001340
institution National Center for Biotechnology Information
language English
publishDate 1986
publisher Nature Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-20013402009-09-10 Localisation of gastrointestinal cancer with a 131 I labelled monoclonal antibody to CEA. Allum, W. H. MacDonald, F. Anderson, P. Fielding, J. W. Br J Cancer Research Article The localisation of tumour deposits by a 131 I labelled monoclonal antibody to carcinoembryonic antigen (CEA) has been evaluated in 24 patients with primary gastric, oesophageal and colorectal cancer and in 26 patients with clinically suspected recurrent gastric and colorectal cancer. Seventeen of 20 primary sites and 6/15 associated secondary sites were correctly identified by external scanning. Measurement of radiolabelled antibody in the resected specimens demonstrated a 2.6-3.3 fold increase in comparison with the surrounding normal tissue (P less than 0.01). The antibody scans were compared with computerised tomography (CT) in the detection of recurrent disease. The respective sensitivities and specificities for the two investigations were 61% and 33% for antibody scanning and 64% and 100% for CT. Assessment of the distribution of labelled antibody demonstrated rapid clearance with less than 2% detectable in serum samples at 24 h. The implications of these findings together with the mechanisms of excretion are discussed. IMAGES: Nature Publishing Group 1986-02 /pmc/articles/PMC2001340/ /pubmed/3954942 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Allum, W. H.
MacDonald, F.
Anderson, P.
Fielding, J. W.
Localisation of gastrointestinal cancer with a 131 I labelled monoclonal antibody to CEA.
title Localisation of gastrointestinal cancer with a 131 I labelled monoclonal antibody to CEA.
title_full Localisation of gastrointestinal cancer with a 131 I labelled monoclonal antibody to CEA.
title_fullStr Localisation of gastrointestinal cancer with a 131 I labelled monoclonal antibody to CEA.
title_full_unstemmed Localisation of gastrointestinal cancer with a 131 I labelled monoclonal antibody to CEA.
title_short Localisation of gastrointestinal cancer with a 131 I labelled monoclonal antibody to CEA.
title_sort localisation of gastrointestinal cancer with a 131 i labelled monoclonal antibody to cea.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2001340/
https://www.ncbi.nlm.nih.gov/pubmed/3954942
work_keys_str_mv AT allumwh localisationofgastrointestinalcancerwitha131ilabelledmonoclonalantibodytocea
AT macdonaldf localisationofgastrointestinalcancerwitha131ilabelledmonoclonalantibodytocea
AT andersonp localisationofgastrointestinalcancerwitha131ilabelledmonoclonalantibodytocea
AT fieldingjw localisationofgastrointestinalcancerwitha131ilabelledmonoclonalantibodytocea

Ejemplares similares