The clinical significance of flow cytometric c-myc oncoprotein quantitation in testicular cancer.

A sensitive flow cytometric assay has been developed using a monoclonal antibody, Myc 1-6E10, to quantitate c-myc oncoprotein levels in nuclei isolated from wax embedded testicular tumours. The oncoprotein (p62c-myc) level increased significantly with increasing teratoma differentiation. Patients wi...

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Detalles Bibliográficos
Autores principales: Watson, J. V., Stewart, J., Evan, G. I., Ritson, A., Sikora, K.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1986
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2001357/
https://www.ncbi.nlm.nih.gov/pubmed/3964537
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author Watson, J. V.
Stewart, J.
Evan, G. I.
Ritson, A.
Sikora, K.
author_facet Watson, J. V.
Stewart, J.
Evan, G. I.
Ritson, A.
Sikora, K.
author_sort Watson, J. V.
collection PubMed
description A sensitive flow cytometric assay has been developed using a monoclonal antibody, Myc 1-6E10, to quantitate c-myc oncoprotein levels in nuclei isolated from wax embedded testicular tumours. The oncoprotein (p62c-myc) level increased significantly with increasing teratoma differentiation. Patients with intermediate and undifferentiated tumours who developed recurrence had lower p62c-myc levels than those who were disease free since their initial treatment. Such quantitative biochemical methods may provide new prognostic indices for cancer patients.
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spelling pubmed-20013572009-09-10 The clinical significance of flow cytometric c-myc oncoprotein quantitation in testicular cancer. Watson, J. V. Stewart, J. Evan, G. I. Ritson, A. Sikora, K. Br J Cancer Research Article A sensitive flow cytometric assay has been developed using a monoclonal antibody, Myc 1-6E10, to quantitate c-myc oncoprotein levels in nuclei isolated from wax embedded testicular tumours. The oncoprotein (p62c-myc) level increased significantly with increasing teratoma differentiation. Patients with intermediate and undifferentiated tumours who developed recurrence had lower p62c-myc levels than those who were disease free since their initial treatment. Such quantitative biochemical methods may provide new prognostic indices for cancer patients. Nature Publishing Group 1986-03 /pmc/articles/PMC2001357/ /pubmed/3964537 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Watson, J. V.
Stewart, J.
Evan, G. I.
Ritson, A.
Sikora, K.
The clinical significance of flow cytometric c-myc oncoprotein quantitation in testicular cancer.
title The clinical significance of flow cytometric c-myc oncoprotein quantitation in testicular cancer.
title_full The clinical significance of flow cytometric c-myc oncoprotein quantitation in testicular cancer.
title_fullStr The clinical significance of flow cytometric c-myc oncoprotein quantitation in testicular cancer.
title_full_unstemmed The clinical significance of flow cytometric c-myc oncoprotein quantitation in testicular cancer.
title_short The clinical significance of flow cytometric c-myc oncoprotein quantitation in testicular cancer.
title_sort clinical significance of flow cytometric c-myc oncoprotein quantitation in testicular cancer.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2001357/
https://www.ncbi.nlm.nih.gov/pubmed/3964537
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