9-alkyl anthracyclines. Absence of cross-resistance to adriamycin in human and murine cell cultures.

Four cell lines of human (CCRF CEM and U266BL) or murine (L1210 and P388D1) origin, resistant to the anthracycline antibiotic Adriamycin (doxorubicin) were selected in vitro from cultured cells by serial passage in the presence of Adriamycin. The resistant sublines were also cross-resistant to Mitox...

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Autores principales: Scott, C. A., Westmacott, D., Broadhurst, M. J., Thomas, G. J., Hall, M. J.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1986
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2001372/
https://www.ncbi.nlm.nih.gov/pubmed/3718817
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author Scott, C. A.
Westmacott, D.
Broadhurst, M. J.
Thomas, G. J.
Hall, M. J.
author_facet Scott, C. A.
Westmacott, D.
Broadhurst, M. J.
Thomas, G. J.
Hall, M. J.
author_sort Scott, C. A.
collection PubMed
description Four cell lines of human (CCRF CEM and U266BL) or murine (L1210 and P388D1) origin, resistant to the anthracycline antibiotic Adriamycin (doxorubicin) were selected in vitro from cultured cells by serial passage in the presence of Adriamycin. The resistant sublines were also cross-resistant to Mitoxantrone, 4'-epi Adriamycin and a number of novel anthracyclines including 4'-deoxy and 4'-methoxy analogues. However, a series of 9-alkyl substituted 4-demethoxyanthracyclines retained full activity against all the resistant sublines as did Aclacinomycin A. These results suggest that 9-alkyl substitution of 4-demethoxy-anthracyclines is an important determinant of activity against Adriamycin-resistant cell lines in vitro.
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spelling pubmed-20013722009-09-10 9-alkyl anthracyclines. Absence of cross-resistance to adriamycin in human and murine cell cultures. Scott, C. A. Westmacott, D. Broadhurst, M. J. Thomas, G. J. Hall, M. J. Br J Cancer Research Article Four cell lines of human (CCRF CEM and U266BL) or murine (L1210 and P388D1) origin, resistant to the anthracycline antibiotic Adriamycin (doxorubicin) were selected in vitro from cultured cells by serial passage in the presence of Adriamycin. The resistant sublines were also cross-resistant to Mitoxantrone, 4'-epi Adriamycin and a number of novel anthracyclines including 4'-deoxy and 4'-methoxy analogues. However, a series of 9-alkyl substituted 4-demethoxyanthracyclines retained full activity against all the resistant sublines as did Aclacinomycin A. These results suggest that 9-alkyl substitution of 4-demethoxy-anthracyclines is an important determinant of activity against Adriamycin-resistant cell lines in vitro. Nature Publishing Group 1986-05 /pmc/articles/PMC2001372/ /pubmed/3718817 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Scott, C. A.
Westmacott, D.
Broadhurst, M. J.
Thomas, G. J.
Hall, M. J.
9-alkyl anthracyclines. Absence of cross-resistance to adriamycin in human and murine cell cultures.
title 9-alkyl anthracyclines. Absence of cross-resistance to adriamycin in human and murine cell cultures.
title_full 9-alkyl anthracyclines. Absence of cross-resistance to adriamycin in human and murine cell cultures.
title_fullStr 9-alkyl anthracyclines. Absence of cross-resistance to adriamycin in human and murine cell cultures.
title_full_unstemmed 9-alkyl anthracyclines. Absence of cross-resistance to adriamycin in human and murine cell cultures.
title_short 9-alkyl anthracyclines. Absence of cross-resistance to adriamycin in human and murine cell cultures.
title_sort 9-alkyl anthracyclines. absence of cross-resistance to adriamycin in human and murine cell cultures.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2001372/
https://www.ncbi.nlm.nih.gov/pubmed/3718817
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