Photodynamic therapy of ascites tumours within the peritoneal cavity.

A murine ascites tumour was treated with intraperitoneal haematoporphyrin derivative (HPD) and laser light (10mW, 514nm, Argon laser). HPD was given intraperitoneally 2 hours before 16 minute laser treatment. Uptake studies 2 hours after HPD injection showed 5-12 fold greater concentration of HPD in...

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Autores principales: Tochner, Z., Mitchell, J. B., Smith, P., Harrington, F., Glatstein, E., Russo, D., Russo, A.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1986
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2001401/
https://www.ncbi.nlm.nih.gov/pubmed/2941046
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author Tochner, Z.
Mitchell, J. B.
Smith, P.
Harrington, F.
Glatstein, E.
Russo, D.
Russo, A.
author_facet Tochner, Z.
Mitchell, J. B.
Smith, P.
Harrington, F.
Glatstein, E.
Russo, D.
Russo, A.
author_sort Tochner, Z.
collection PubMed
description A murine ascites tumour was treated with intraperitoneal haematoporphyrin derivative (HPD) and laser light (10mW, 514nm, Argon laser). HPD was given intraperitoneally 2 hours before 16 minute laser treatment. Uptake studies 2 hours after HPD injection showed 5-12 fold greater concentration of HPD in tumour cells than in 4 different normal tissues. A total of four HPD/laser treatments, given at 2 day intervals, resulted in 100% complete response; the cure rate was 85%. This study illustrates the effective use of intraperitoneal photodynamic therapy and opens the possibility of exploring different sensitizers, excitation wavelengths, and delivery systems in the treatment of human ascites tumours.
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spelling pubmed-20014012009-09-10 Photodynamic therapy of ascites tumours within the peritoneal cavity. Tochner, Z. Mitchell, J. B. Smith, P. Harrington, F. Glatstein, E. Russo, D. Russo, A. Br J Cancer Research Article A murine ascites tumour was treated with intraperitoneal haematoporphyrin derivative (HPD) and laser light (10mW, 514nm, Argon laser). HPD was given intraperitoneally 2 hours before 16 minute laser treatment. Uptake studies 2 hours after HPD injection showed 5-12 fold greater concentration of HPD in tumour cells than in 4 different normal tissues. A total of four HPD/laser treatments, given at 2 day intervals, resulted in 100% complete response; the cure rate was 85%. This study illustrates the effective use of intraperitoneal photodynamic therapy and opens the possibility of exploring different sensitizers, excitation wavelengths, and delivery systems in the treatment of human ascites tumours. Nature Publishing Group 1986-06 /pmc/articles/PMC2001401/ /pubmed/2941046 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Tochner, Z.
Mitchell, J. B.
Smith, P.
Harrington, F.
Glatstein, E.
Russo, D.
Russo, A.
Photodynamic therapy of ascites tumours within the peritoneal cavity.
title Photodynamic therapy of ascites tumours within the peritoneal cavity.
title_full Photodynamic therapy of ascites tumours within the peritoneal cavity.
title_fullStr Photodynamic therapy of ascites tumours within the peritoneal cavity.
title_full_unstemmed Photodynamic therapy of ascites tumours within the peritoneal cavity.
title_short Photodynamic therapy of ascites tumours within the peritoneal cavity.
title_sort photodynamic therapy of ascites tumours within the peritoneal cavity.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2001401/
https://www.ncbi.nlm.nih.gov/pubmed/2941046
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