Antibody-guided irradiation of malignant pleural and pericardial effusions.

Tumour-associated monoclonal antibodies (HMFG1, HMFG2 and AUA1) radiolabelled with iodine-131 were given intracavitary (intrapleurally and intrapericardially) to patients with malignant effusions. Ten out of 13 effusions (3 pericardial and 7 pleural) responded completely with no fluid reaccumulation...

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Autores principales: Pectasides, D., Stewart, S., Courtenay-Luck, N., Rampling, R., Munro, A. J., Krausz, T., Dhokia, B., Snook, D., Hooker, G., Durbin, H.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1986
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2001403/
https://www.ncbi.nlm.nih.gov/pubmed/3718827
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author Pectasides, D.
Stewart, S.
Courtenay-Luck, N.
Rampling, R.
Munro, A. J.
Krausz, T.
Dhokia, B.
Snook, D.
Hooker, G.
Durbin, H.
author_facet Pectasides, D.
Stewart, S.
Courtenay-Luck, N.
Rampling, R.
Munro, A. J.
Krausz, T.
Dhokia, B.
Snook, D.
Hooker, G.
Durbin, H.
author_sort Pectasides, D.
collection PubMed
description Tumour-associated monoclonal antibodies (HMFG1, HMFG2 and AUA1) radiolabelled with iodine-131 were given intracavitary (intrapleurally and intrapericardially) to patients with malignant effusions. Ten out of 13 effusions (3 pericardial and 7 pleural) responded completely with no fluid reaccumulation between 3 and 18 months. No clinical or other toxicity was observed. This new method of treatment for recurrent malignant effusions is non-toxic and effective resulting in improved quality of life, and, in some cases, prolongation of survival.
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spelling pubmed-20014032009-09-10 Antibody-guided irradiation of malignant pleural and pericardial effusions. Pectasides, D. Stewart, S. Courtenay-Luck, N. Rampling, R. Munro, A. J. Krausz, T. Dhokia, B. Snook, D. Hooker, G. Durbin, H. Br J Cancer Research Article Tumour-associated monoclonal antibodies (HMFG1, HMFG2 and AUA1) radiolabelled with iodine-131 were given intracavitary (intrapleurally and intrapericardially) to patients with malignant effusions. Ten out of 13 effusions (3 pericardial and 7 pleural) responded completely with no fluid reaccumulation between 3 and 18 months. No clinical or other toxicity was observed. This new method of treatment for recurrent malignant effusions is non-toxic and effective resulting in improved quality of life, and, in some cases, prolongation of survival. Nature Publishing Group 1986-06 /pmc/articles/PMC2001403/ /pubmed/3718827 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Pectasides, D.
Stewart, S.
Courtenay-Luck, N.
Rampling, R.
Munro, A. J.
Krausz, T.
Dhokia, B.
Snook, D.
Hooker, G.
Durbin, H.
Antibody-guided irradiation of malignant pleural and pericardial effusions.
title Antibody-guided irradiation of malignant pleural and pericardial effusions.
title_full Antibody-guided irradiation of malignant pleural and pericardial effusions.
title_fullStr Antibody-guided irradiation of malignant pleural and pericardial effusions.
title_full_unstemmed Antibody-guided irradiation of malignant pleural and pericardial effusions.
title_short Antibody-guided irradiation of malignant pleural and pericardial effusions.
title_sort antibody-guided irradiation of malignant pleural and pericardial effusions.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2001403/
https://www.ncbi.nlm.nih.gov/pubmed/3718827
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