The in vivo malignant transformation of mouse fibroblasts in the presence of human tumour xenografts.

During the routine serial passage of over 30 human tumour xenografts in athymic (nu. nu.) mice over a period of 6 years the induction of murine fibrosarcomas at the site of transplantation has been observed on three occasions. In two cases it has been possible to follow the development of these tumo...

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Detalles Bibliográficos
Autores principales: Sparrow, S., Jones, M., Billington, S., Stace, B.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1986
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2001411/
https://www.ncbi.nlm.nih.gov/pubmed/3013267
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author Sparrow, S.
Jones, M.
Billington, S.
Stace, B.
author_facet Sparrow, S.
Jones, M.
Billington, S.
Stace, B.
author_sort Sparrow, S.
collection PubMed
description During the routine serial passage of over 30 human tumour xenografts in athymic (nu. nu.) mice over a period of 6 years the induction of murine fibrosarcomas at the site of transplantation has been observed on three occasions. In two cases it has been possible to follow the development of these tumours over successive transplant generations. These sarcomas had growth rates, tumour karyotypes and isoenzyme patterns which clearly distinguished them from the original human xenografts. IMAGES:
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spelling pubmed-20014112009-09-10 The in vivo malignant transformation of mouse fibroblasts in the presence of human tumour xenografts. Sparrow, S. Jones, M. Billington, S. Stace, B. Br J Cancer Research Article During the routine serial passage of over 30 human tumour xenografts in athymic (nu. nu.) mice over a period of 6 years the induction of murine fibrosarcomas at the site of transplantation has been observed on three occasions. In two cases it has been possible to follow the development of these tumours over successive transplant generations. These sarcomas had growth rates, tumour karyotypes and isoenzyme patterns which clearly distinguished them from the original human xenografts. IMAGES: Nature Publishing Group 1986-06 /pmc/articles/PMC2001411/ /pubmed/3013267 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Sparrow, S.
Jones, M.
Billington, S.
Stace, B.
The in vivo malignant transformation of mouse fibroblasts in the presence of human tumour xenografts.
title The in vivo malignant transformation of mouse fibroblasts in the presence of human tumour xenografts.
title_full The in vivo malignant transformation of mouse fibroblasts in the presence of human tumour xenografts.
title_fullStr The in vivo malignant transformation of mouse fibroblasts in the presence of human tumour xenografts.
title_full_unstemmed The in vivo malignant transformation of mouse fibroblasts in the presence of human tumour xenografts.
title_short The in vivo malignant transformation of mouse fibroblasts in the presence of human tumour xenografts.
title_sort in vivo malignant transformation of mouse fibroblasts in the presence of human tumour xenografts.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2001411/
https://www.ncbi.nlm.nih.gov/pubmed/3013267
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