Thyroid blood group isoantigen expression: a parallel with ABH isoantigen expression in the distal colon.

An interesting and not previously reported parallel has been observed between the known pattern of ABO (H) blood group isoantigen expression in normal and neoplastic colonic epithelium and that in the thyroid. Epithelial expression of blood group isoantigens was not observed in 16 specimens of norma...

Descripción completa

Detalles Bibliográficos
Autores principales: Vowden, P., Lowe, A. D., Lennox, E. S., Bleehen, N. M.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1986
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2001419/
https://www.ncbi.nlm.nih.gov/pubmed/3521695
_version_ 1782135600894181376
author Vowden, P.
Lowe, A. D.
Lennox, E. S.
Bleehen, N. M.
author_facet Vowden, P.
Lowe, A. D.
Lennox, E. S.
Bleehen, N. M.
author_sort Vowden, P.
collection PubMed
description An interesting and not previously reported parallel has been observed between the known pattern of ABO (H) blood group isoantigen expression in normal and neoplastic colonic epithelium and that in the thyroid. Epithelial expression of blood group isoantigens was not observed in 16 specimens of normal or non-neoplastic thyroid tissue. This contrasts with the progressive re-expression of these antigens in neoplastic thyroid tissue. Blood group isoantigens were detected in two of eight papillary adenomas and 13 of 17 papillary carcinomas. Antigen expression was in part related to differentiation, and stained cells were less readily detected in follicular tumours, only one of five adenomas and two of seven carcinomas displaying blood group antigens while three medullary and two anaplastic carcinomas were antigen-deficient. IMAGES:
format Text
id pubmed-2001419
institution National Center for Biotechnology Information
language English
publishDate 1986
publisher Nature Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-20014192009-09-10 Thyroid blood group isoantigen expression: a parallel with ABH isoantigen expression in the distal colon. Vowden, P. Lowe, A. D. Lennox, E. S. Bleehen, N. M. Br J Cancer Research Article An interesting and not previously reported parallel has been observed between the known pattern of ABO (H) blood group isoantigen expression in normal and neoplastic colonic epithelium and that in the thyroid. Epithelial expression of blood group isoantigens was not observed in 16 specimens of normal or non-neoplastic thyroid tissue. This contrasts with the progressive re-expression of these antigens in neoplastic thyroid tissue. Blood group isoantigens were detected in two of eight papillary adenomas and 13 of 17 papillary carcinomas. Antigen expression was in part related to differentiation, and stained cells were less readily detected in follicular tumours, only one of five adenomas and two of seven carcinomas displaying blood group antigens while three medullary and two anaplastic carcinomas were antigen-deficient. IMAGES: Nature Publishing Group 1986-06 /pmc/articles/PMC2001419/ /pubmed/3521695 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Vowden, P.
Lowe, A. D.
Lennox, E. S.
Bleehen, N. M.
Thyroid blood group isoantigen expression: a parallel with ABH isoantigen expression in the distal colon.
title Thyroid blood group isoantigen expression: a parallel with ABH isoantigen expression in the distal colon.
title_full Thyroid blood group isoantigen expression: a parallel with ABH isoantigen expression in the distal colon.
title_fullStr Thyroid blood group isoantigen expression: a parallel with ABH isoantigen expression in the distal colon.
title_full_unstemmed Thyroid blood group isoantigen expression: a parallel with ABH isoantigen expression in the distal colon.
title_short Thyroid blood group isoantigen expression: a parallel with ABH isoantigen expression in the distal colon.
title_sort thyroid blood group isoantigen expression: a parallel with abh isoantigen expression in the distal colon.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2001419/
https://www.ncbi.nlm.nih.gov/pubmed/3521695
work_keys_str_mv AT vowdenp thyroidbloodgroupisoantigenexpressionaparallelwithabhisoantigenexpressioninthedistalcolon
AT lowead thyroidbloodgroupisoantigenexpressionaparallelwithabhisoantigenexpressioninthedistalcolon
AT lennoxes thyroidbloodgroupisoantigenexpressionaparallelwithabhisoantigenexpressioninthedistalcolon
AT bleehennm thyroidbloodgroupisoantigenexpressionaparallelwithabhisoantigenexpressioninthedistalcolon

Ejemplares similares