Measurement of high molecular weight forms of enzymes in serum in the detection of hepatic metastases of colorectal cancer.

Total gamma-glutamyl transferase and alkaline phosphatase, liver-specific alkaline phosphatase and high molecular weight forms of the two enzymes were measured in the sera of 42 patients with colorectal cancer, of whom 26 were apparently metastases-free and 16 had palpable liver metastases. The aver...

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Autores principales: Traynor, O. J., Wood, C. B., Echetebu, Z. O., Whitaker, K. B., Moss, D. W.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1986
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2001446/
https://www.ncbi.nlm.nih.gov/pubmed/2871859
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author Traynor, O. J.
Wood, C. B.
Echetebu, Z. O.
Whitaker, K. B.
Moss, D. W.
author_facet Traynor, O. J.
Wood, C. B.
Echetebu, Z. O.
Whitaker, K. B.
Moss, D. W.
author_sort Traynor, O. J.
collection PubMed
description Total gamma-glutamyl transferase and alkaline phosphatase, liver-specific alkaline phosphatase and high molecular weight forms of the two enzymes were measured in the sera of 42 patients with colorectal cancer, of whom 26 were apparently metastases-free and 16 had palpable liver metastases. The average levels of all enzymes were significantly higher in the group with metastases, but there was considerable overlap between the groups. The predictive values of positive results were of the order of 50-75%; predictive values of negative results were more than 70% for all tests, with high molecular weight alkaline phosphatase (87%) performing best in this respect. However, measurement of high molecular weight enzymes does not offer marked advantages over more conventional enzyme tests in the detection of hepatic metastases of colorectal cancer.
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spelling pubmed-20014462009-09-10 Measurement of high molecular weight forms of enzymes in serum in the detection of hepatic metastases of colorectal cancer. Traynor, O. J. Wood, C. B. Echetebu, Z. O. Whitaker, K. B. Moss, D. W. Br J Cancer Research Article Total gamma-glutamyl transferase and alkaline phosphatase, liver-specific alkaline phosphatase and high molecular weight forms of the two enzymes were measured in the sera of 42 patients with colorectal cancer, of whom 26 were apparently metastases-free and 16 had palpable liver metastases. The average levels of all enzymes were significantly higher in the group with metastases, but there was considerable overlap between the groups. The predictive values of positive results were of the order of 50-75%; predictive values of negative results were more than 70% for all tests, with high molecular weight alkaline phosphatase (87%) performing best in this respect. However, measurement of high molecular weight enzymes does not offer marked advantages over more conventional enzyme tests in the detection of hepatic metastases of colorectal cancer. Nature Publishing Group 1986-04 /pmc/articles/PMC2001446/ /pubmed/2871859 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Traynor, O. J.
Wood, C. B.
Echetebu, Z. O.
Whitaker, K. B.
Moss, D. W.
Measurement of high molecular weight forms of enzymes in serum in the detection of hepatic metastases of colorectal cancer.
title Measurement of high molecular weight forms of enzymes in serum in the detection of hepatic metastases of colorectal cancer.
title_full Measurement of high molecular weight forms of enzymes in serum in the detection of hepatic metastases of colorectal cancer.
title_fullStr Measurement of high molecular weight forms of enzymes in serum in the detection of hepatic metastases of colorectal cancer.
title_full_unstemmed Measurement of high molecular weight forms of enzymes in serum in the detection of hepatic metastases of colorectal cancer.
title_short Measurement of high molecular weight forms of enzymes in serum in the detection of hepatic metastases of colorectal cancer.
title_sort measurement of high molecular weight forms of enzymes in serum in the detection of hepatic metastases of colorectal cancer.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2001446/
https://www.ncbi.nlm.nih.gov/pubmed/2871859
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