Role of aminoglutethimide in male breast cancer.

Five men with advanced breast cancer were treated with aminoglutethimide (AG) plus replacement dose hydrocortisone. None of the 4 patients with intact testes responded, although 3 did so subsequently to tamoxifen. The previously orchidectomized patient responded to aminoglutethimide for 14 months. O...

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Detalles Bibliográficos
Autores principales: Harris, A. L., Dowsett, M., Stuart-Harris, R., Smith, I. E.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1986
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2001494/
https://www.ncbi.nlm.nih.gov/pubmed/3778807
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author Harris, A. L.
Dowsett, M.
Stuart-Harris, R.
Smith, I. E.
author_facet Harris, A. L.
Dowsett, M.
Stuart-Harris, R.
Smith, I. E.
author_sort Harris, A. L.
collection PubMed
description Five men with advanced breast cancer were treated with aminoglutethimide (AG) plus replacement dose hydrocortisone. None of the 4 patients with intact testes responded, although 3 did so subsequently to tamoxifen. The previously orchidectomized patient responded to aminoglutethimide for 14 months. Oestrone and oestradiol were suppressed by AG in all patients, but not to the levels achieved by orchidectomy. AG produced substantial further oestrogen suppression in the orchidectomized patient and should only be used after orchidectomy. IMAGES:
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spelling pubmed-20014942009-09-10 Role of aminoglutethimide in male breast cancer. Harris, A. L. Dowsett, M. Stuart-Harris, R. Smith, I. E. Br J Cancer Research Article Five men with advanced breast cancer were treated with aminoglutethimide (AG) plus replacement dose hydrocortisone. None of the 4 patients with intact testes responded, although 3 did so subsequently to tamoxifen. The previously orchidectomized patient responded to aminoglutethimide for 14 months. Oestrone and oestradiol were suppressed by AG in all patients, but not to the levels achieved by orchidectomy. AG produced substantial further oestrogen suppression in the orchidectomized patient and should only be used after orchidectomy. IMAGES: Nature Publishing Group 1986-10 /pmc/articles/PMC2001494/ /pubmed/3778807 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Harris, A. L.
Dowsett, M.
Stuart-Harris, R.
Smith, I. E.
Role of aminoglutethimide in male breast cancer.
title Role of aminoglutethimide in male breast cancer.
title_full Role of aminoglutethimide in male breast cancer.
title_fullStr Role of aminoglutethimide in male breast cancer.
title_full_unstemmed Role of aminoglutethimide in male breast cancer.
title_short Role of aminoglutethimide in male breast cancer.
title_sort role of aminoglutethimide in male breast cancer.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2001494/
https://www.ncbi.nlm.nih.gov/pubmed/3778807
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