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The effect of passage in vivo and in vitro on the properties of murine fibrosarcomas: III. Cell surface molecules and production of growth factors.
Three factors may be responsible for the sharp difference in tumourigenicity between cloned murine fibrosarcoma lines maintained in vitro, and cells of the same lines after in vivo passage, initially in a T cell deficient mouse and subsequently in normal mice: acquisition during passage of resistanc...
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Formato: | Texto |
Lenguaje: | English |
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Nature Publishing Group
1986
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2001501/ https://www.ncbi.nlm.nih.gov/pubmed/3490872 |
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author | Woodruff, M. F. Hodson, B. A. Deane, D. L. |
author_facet | Woodruff, M. F. Hodson, B. A. Deane, D. L. |
author_sort | Woodruff, M. F. |
collection | PubMed |
description | Three factors may be responsible for the sharp difference in tumourigenicity between cloned murine fibrosarcoma lines maintained in vitro, and cells of the same lines after in vivo passage, initially in a T cell deficient mouse and subsequently in normal mice: acquisition during passage of resistance to NC cells; acquisition during passage of a surface molecule, probably a sialic acid, which protects the cell against T cell-mediated lysis; and ability of the passaged cells, but not the non-passaged cells, to produce sufficient amounts of autocrine growth factors necessary for growth in vivo. The tumourigenicity of the passaged cells cannot be attributed to failure to express TATA or MHC class I molecules. IMAGES: |
format | Text |
id | pubmed-2001501 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 1986 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-20015012009-09-10 The effect of passage in vivo and in vitro on the properties of murine fibrosarcomas: III. Cell surface molecules and production of growth factors. Woodruff, M. F. Hodson, B. A. Deane, D. L. Br J Cancer Research Article Three factors may be responsible for the sharp difference in tumourigenicity between cloned murine fibrosarcoma lines maintained in vitro, and cells of the same lines after in vivo passage, initially in a T cell deficient mouse and subsequently in normal mice: acquisition during passage of resistance to NC cells; acquisition during passage of a surface molecule, probably a sialic acid, which protects the cell against T cell-mediated lysis; and ability of the passaged cells, but not the non-passaged cells, to produce sufficient amounts of autocrine growth factors necessary for growth in vivo. The tumourigenicity of the passaged cells cannot be attributed to failure to express TATA or MHC class I molecules. IMAGES: Nature Publishing Group 1986-10 /pmc/articles/PMC2001501/ /pubmed/3490872 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Research Article Woodruff, M. F. Hodson, B. A. Deane, D. L. The effect of passage in vivo and in vitro on the properties of murine fibrosarcomas: III. Cell surface molecules and production of growth factors. |
title | The effect of passage in vivo and in vitro on the properties of murine fibrosarcomas: III. Cell surface molecules and production of growth factors. |
title_full | The effect of passage in vivo and in vitro on the properties of murine fibrosarcomas: III. Cell surface molecules and production of growth factors. |
title_fullStr | The effect of passage in vivo and in vitro on the properties of murine fibrosarcomas: III. Cell surface molecules and production of growth factors. |
title_full_unstemmed | The effect of passage in vivo and in vitro on the properties of murine fibrosarcomas: III. Cell surface molecules and production of growth factors. |
title_short | The effect of passage in vivo and in vitro on the properties of murine fibrosarcomas: III. Cell surface molecules and production of growth factors. |
title_sort | effect of passage in vivo and in vitro on the properties of murine fibrosarcomas: iii. cell surface molecules and production of growth factors. |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2001501/ https://www.ncbi.nlm.nih.gov/pubmed/3490872 |
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