The relationship between cisplatin sensitivity and drug uptake into mammalian cells in vitro.

Clonogenic survival of HeLa, Chinese hamster and HaK cells after treatment with a range of cisplatin concentrations and exposure times was determined and cellular platinum concentrations were measured by PIXE. It was demonstrated that cisplatin cytotoxicity of the three cell lines varied considerabl...

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Autores principales: Eichholtz-Wirth, H., Hietel, B.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1986
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2001512/
https://www.ncbi.nlm.nih.gov/pubmed/3741760
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author Eichholtz-Wirth, H.
Hietel, B.
author_facet Eichholtz-Wirth, H.
Hietel, B.
author_sort Eichholtz-Wirth, H.
collection PubMed
description Clonogenic survival of HeLa, Chinese hamster and HaK cells after treatment with a range of cisplatin concentrations and exposure times was determined and cellular platinum concentrations were measured by PIXE. It was demonstrated that cisplatin cytotoxicity of the three cell lines varied considerably as a function of drug exposure dose. These differences are related to differential cellular drug uptake.
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spelling pubmed-20015122009-09-10 The relationship between cisplatin sensitivity and drug uptake into mammalian cells in vitro. Eichholtz-Wirth, H. Hietel, B. Br J Cancer Research Article Clonogenic survival of HeLa, Chinese hamster and HaK cells after treatment with a range of cisplatin concentrations and exposure times was determined and cellular platinum concentrations were measured by PIXE. It was demonstrated that cisplatin cytotoxicity of the three cell lines varied considerably as a function of drug exposure dose. These differences are related to differential cellular drug uptake. Nature Publishing Group 1986-08 /pmc/articles/PMC2001512/ /pubmed/3741760 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Eichholtz-Wirth, H.
Hietel, B.
The relationship between cisplatin sensitivity and drug uptake into mammalian cells in vitro.
title The relationship between cisplatin sensitivity and drug uptake into mammalian cells in vitro.
title_full The relationship between cisplatin sensitivity and drug uptake into mammalian cells in vitro.
title_fullStr The relationship between cisplatin sensitivity and drug uptake into mammalian cells in vitro.
title_full_unstemmed The relationship between cisplatin sensitivity and drug uptake into mammalian cells in vitro.
title_short The relationship between cisplatin sensitivity and drug uptake into mammalian cells in vitro.
title_sort relationship between cisplatin sensitivity and drug uptake into mammalian cells in vitro.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2001512/
https://www.ncbi.nlm.nih.gov/pubmed/3741760
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