Inhibitors of adriamycin-induced histamine release in vitro limit adriamycin cardiotoxicity in vivo.

The activity of theophylline and disodium cromoglycate was tested on adriamycin-induced histamine release in vitro and on adriamycin cardiotoxicity in vivo. Both substances significantly inhibited the release of histamine induced by 100 micrograms ml-1 of adriamycin on rat peritoneal cells and produ...

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Autores principales: Klugmann, F. B., Decorti, G., Candussio, L., Grill, V., Mallardi, F., Baldini, L.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1986
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2001538/
https://www.ncbi.nlm.nih.gov/pubmed/2432914
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author Klugmann, F. B.
Decorti, G.
Candussio, L.
Grill, V.
Mallardi, F.
Baldini, L.
author_facet Klugmann, F. B.
Decorti, G.
Candussio, L.
Grill, V.
Mallardi, F.
Baldini, L.
author_sort Klugmann, F. B.
collection PubMed
description The activity of theophylline and disodium cromoglycate was tested on adriamycin-induced histamine release in vitro and on adriamycin cardiotoxicity in vivo. Both substances significantly inhibited the release of histamine induced by 100 micrograms ml-1 of adriamycin on rat peritoneal cells and produced significant protection against adriamycin-mediated acute and chronic cardiotoxicity in mice. N-acetylcysteine, a free radical scavenger, successfully used in the prevention of the cardiomyopathy, was also found to be an inhibitor of histamine release induced by adriamycin and compound 48/80 on rat peritoneal cells. This study further supports the hypothesis that the release of histamine may be involved in the pathogenesis of anthracycline cardiotoxicity. IMAGES:
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spelling pubmed-20015382009-09-10 Inhibitors of adriamycin-induced histamine release in vitro limit adriamycin cardiotoxicity in vivo. Klugmann, F. B. Decorti, G. Candussio, L. Grill, V. Mallardi, F. Baldini, L. Br J Cancer Research Article The activity of theophylline and disodium cromoglycate was tested on adriamycin-induced histamine release in vitro and on adriamycin cardiotoxicity in vivo. Both substances significantly inhibited the release of histamine induced by 100 micrograms ml-1 of adriamycin on rat peritoneal cells and produced significant protection against adriamycin-mediated acute and chronic cardiotoxicity in mice. N-acetylcysteine, a free radical scavenger, successfully used in the prevention of the cardiomyopathy, was also found to be an inhibitor of histamine release induced by adriamycin and compound 48/80 on rat peritoneal cells. This study further supports the hypothesis that the release of histamine may be involved in the pathogenesis of anthracycline cardiotoxicity. IMAGES: Nature Publishing Group 1986-11 /pmc/articles/PMC2001538/ /pubmed/2432914 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Klugmann, F. B.
Decorti, G.
Candussio, L.
Grill, V.
Mallardi, F.
Baldini, L.
Inhibitors of adriamycin-induced histamine release in vitro limit adriamycin cardiotoxicity in vivo.
title Inhibitors of adriamycin-induced histamine release in vitro limit adriamycin cardiotoxicity in vivo.
title_full Inhibitors of adriamycin-induced histamine release in vitro limit adriamycin cardiotoxicity in vivo.
title_fullStr Inhibitors of adriamycin-induced histamine release in vitro limit adriamycin cardiotoxicity in vivo.
title_full_unstemmed Inhibitors of adriamycin-induced histamine release in vitro limit adriamycin cardiotoxicity in vivo.
title_short Inhibitors of adriamycin-induced histamine release in vitro limit adriamycin cardiotoxicity in vivo.
title_sort inhibitors of adriamycin-induced histamine release in vitro limit adriamycin cardiotoxicity in vivo.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2001538/
https://www.ncbi.nlm.nih.gov/pubmed/2432914
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