Testosterone-induced DNA synthesis in cultured rat ventral prostate: effects of estracyt and its derivatives.

Testosterone-induced DNA synthesis in cultured rat ventral prostate was used to compare the direct effects of Estracyt and Emcyt with that of their metabolite, estramustine, and their carrier-hormone, oestradiol-17 beta on prostatic growth. In serum-supplemented medium (5-20% FCS), all the compounds...

Descripción completa

Detalles Bibliográficos
Autores principales: Buchanan, L. J., Riches, A. C.
Formato: Texto
Lenguaje:English
Publicado: Nature Publishing Group 1987
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2001568/
https://www.ncbi.nlm.nih.gov/pubmed/3814475
_version_ 1782135631834513408
author Buchanan, L. J.
Riches, A. C.
author_facet Buchanan, L. J.
Riches, A. C.
author_sort Buchanan, L. J.
collection PubMed
description Testosterone-induced DNA synthesis in cultured rat ventral prostate was used to compare the direct effects of Estracyt and Emcyt with that of their metabolite, estramustine, and their carrier-hormone, oestradiol-17 beta on prostatic growth. In serum-supplemented medium (5-20% FCS), all the compounds were equally effective in suppressing testosterone stimulated DNA synthesis which was reduced by between 40-50%, whereas in serum-free medium the estramustine compounds were consistently less effective than oestradiol-17 beta. In the presence of 4 X 10(-9) M testosterone in serum-free medium, stimulated DNA synthesis was reduced by 15-30% following incubation with 4 X 10(-7) M of Estracyt, Emcyt and estramustine and by 60% with 4 X 10(-7) M oestradiol-17 beta. Thus, none of the estramustine compounds appear to offer any selective advantage over that of oestradiol-17 beta in suppressing prostatic DNA synthesis at the target tissue level. IMAGES:
format Text
id pubmed-2001568
institution National Center for Biotechnology Information
language English
publishDate 1987
publisher Nature Publishing Group
record_format MEDLINE/PubMed
spelling pubmed-20015682009-09-10 Testosterone-induced DNA synthesis in cultured rat ventral prostate: effects of estracyt and its derivatives. Buchanan, L. J. Riches, A. C. Br J Cancer Research Article Testosterone-induced DNA synthesis in cultured rat ventral prostate was used to compare the direct effects of Estracyt and Emcyt with that of their metabolite, estramustine, and their carrier-hormone, oestradiol-17 beta on prostatic growth. In serum-supplemented medium (5-20% FCS), all the compounds were equally effective in suppressing testosterone stimulated DNA synthesis which was reduced by between 40-50%, whereas in serum-free medium the estramustine compounds were consistently less effective than oestradiol-17 beta. In the presence of 4 X 10(-9) M testosterone in serum-free medium, stimulated DNA synthesis was reduced by 15-30% following incubation with 4 X 10(-7) M of Estracyt, Emcyt and estramustine and by 60% with 4 X 10(-7) M oestradiol-17 beta. Thus, none of the estramustine compounds appear to offer any selective advantage over that of oestradiol-17 beta in suppressing prostatic DNA synthesis at the target tissue level. IMAGES: Nature Publishing Group 1987-01 /pmc/articles/PMC2001568/ /pubmed/3814475 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
spellingShingle Research Article
Buchanan, L. J.
Riches, A. C.
Testosterone-induced DNA synthesis in cultured rat ventral prostate: effects of estracyt and its derivatives.
title Testosterone-induced DNA synthesis in cultured rat ventral prostate: effects of estracyt and its derivatives.
title_full Testosterone-induced DNA synthesis in cultured rat ventral prostate: effects of estracyt and its derivatives.
title_fullStr Testosterone-induced DNA synthesis in cultured rat ventral prostate: effects of estracyt and its derivatives.
title_full_unstemmed Testosterone-induced DNA synthesis in cultured rat ventral prostate: effects of estracyt and its derivatives.
title_short Testosterone-induced DNA synthesis in cultured rat ventral prostate: effects of estracyt and its derivatives.
title_sort testosterone-induced dna synthesis in cultured rat ventral prostate: effects of estracyt and its derivatives.
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2001568/
https://www.ncbi.nlm.nih.gov/pubmed/3814475
work_keys_str_mv AT buchananlj testosteroneinduceddnasynthesisinculturedratventralprostateeffectsofestracytanditsderivatives
AT richesac testosteroneinduceddnasynthesisinculturedratventralprostateeffectsofestracytanditsderivatives

Ejemplares similares