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Variations in exposure to mitomycin C in an in vitro colony-forming assay.
The effect of mitomycin C on two human ovarian cancer cell lines was measured during several exposure times and concentrations using the Human Tumour Colony-forming Assay (HTCA). Changes in exposure time and concentration resulted in considerable differences in tumour cell survival. It is concluded...
| Autores principales: | , , , , , |
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| Formato: | Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group
1986
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2001588/ https://www.ncbi.nlm.nih.gov/pubmed/3099819 |
| _version_ | 1782135635636649984 |
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| author | Slee, P. H. de Bruijn, E. A. Leeflang, P. Kuppen, P. J. van den Berg, L. van Oosterom, A. T. |
| author_facet | Slee, P. H. de Bruijn, E. A. Leeflang, P. Kuppen, P. J. van den Berg, L. van Oosterom, A. T. |
| author_sort | Slee, P. H. |
| collection | PubMed |
| description | The effect of mitomycin C on two human ovarian cancer cell lines was measured during several exposure times and concentrations using the Human Tumour Colony-forming Assay (HTCA). Changes in exposure time and concentration resulted in considerable differences in tumour cell survival. It is concluded that several exposure times and concentrations are necessary for in vitro sensitivity testing. We suggest alternative criteria derived from pharmacokinetic data in patients instead of one-tenth of the peak plasma level which is the usual practice. |
| format | Text |
| id | pubmed-2001588 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 1986 |
| publisher | Nature Publishing Group |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-20015882009-09-10 Variations in exposure to mitomycin C in an in vitro colony-forming assay. Slee, P. H. de Bruijn, E. A. Leeflang, P. Kuppen, P. J. van den Berg, L. van Oosterom, A. T. Br J Cancer Research Article The effect of mitomycin C on two human ovarian cancer cell lines was measured during several exposure times and concentrations using the Human Tumour Colony-forming Assay (HTCA). Changes in exposure time and concentration resulted in considerable differences in tumour cell survival. It is concluded that several exposure times and concentrations are necessary for in vitro sensitivity testing. We suggest alternative criteria derived from pharmacokinetic data in patients instead of one-tenth of the peak plasma level which is the usual practice. Nature Publishing Group 1986-12 /pmc/articles/PMC2001588/ /pubmed/3099819 Text en https://creativecommons.org/licenses/by/4.0/This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/. |
| spellingShingle | Research Article Slee, P. H. de Bruijn, E. A. Leeflang, P. Kuppen, P. J. van den Berg, L. van Oosterom, A. T. Variations in exposure to mitomycin C in an in vitro colony-forming assay. |
| title | Variations in exposure to mitomycin C in an in vitro colony-forming assay. |
| title_full | Variations in exposure to mitomycin C in an in vitro colony-forming assay. |
| title_fullStr | Variations in exposure to mitomycin C in an in vitro colony-forming assay. |
| title_full_unstemmed | Variations in exposure to mitomycin C in an in vitro colony-forming assay. |
| title_short | Variations in exposure to mitomycin C in an in vitro colony-forming assay. |
| title_sort | variations in exposure to mitomycin c in an in vitro colony-forming assay. |
| topic | Research Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2001588/ https://www.ncbi.nlm.nih.gov/pubmed/3099819 |
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